Wang Xiang, Huang Jianping, Wang Yupeng, Wang Qilong, Jing Yajiang, Zhang Gang, Peng Liang, Gao Jing, Wang Hongyan, Yan Yonggang
{"title":"不同配比的大黄-桃仁药效学差异的代谢物分析。","authors":"Wang Xiang, Huang Jianping, Wang Yupeng, Wang Qilong, Jing Yajiang, Zhang Gang, Peng Liang, Gao Jing, Wang Hongyan, Yan Yonggang","doi":"10.19852/j.cnki.jtcm.20240423.006","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the material basis of the difference of efficacy of Dahuang (<i>Radix Et Rhizoma Rhei Palmati</i>)-Taoren (<i>Semen Persica</i>e) (DT) drugs with different proportions.</p><p><strong>Methods: </strong>Samples of different ratios of Dahuang (<i>Radix et Rhizoma Rhei Palnati</i>, DH) to Taoren (<i>Semen Persicae</i>, TR) (Group A 1:1, B 2:3, C 3:2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.</p><p><strong>Results: </strong>A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid (phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway.</p><p><strong>Conclusion: </strong>There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1:1.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 3","pages":"515-523"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077142/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang ()-Taoren () herb pair.\",\"authors\":\"Wang Xiang, Huang Jianping, Wang Yupeng, Wang Qilong, Jing Yajiang, Zhang Gang, Peng Liang, Gao Jing, Wang Hongyan, Yan Yonggang\",\"doi\":\"10.19852/j.cnki.jtcm.20240423.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the material basis of the difference of efficacy of Dahuang (<i>Radix Et Rhizoma Rhei Palmati</i>)-Taoren (<i>Semen Persica</i>e) (DT) drugs with different proportions.</p><p><strong>Methods: </strong>Samples of different ratios of Dahuang (<i>Radix et Rhizoma Rhei Palnati</i>, DH) to Taoren (<i>Semen Persicae</i>, TR) (Group A 1:1, B 2:3, C 3:2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.</p><p><strong>Results: </strong>A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid (phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway.</p><p><strong>Conclusion: </strong>There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1:1.</p>\",\"PeriodicalId\":94119,\"journal\":{\"name\":\"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan\",\"volume\":\"44 3\",\"pages\":\"515-523\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077142/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19852/j.cnki.jtcm.20240423.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19852/j.cnki.jtcm.20240423.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang ()-Taoren () herb pair.
Objective: To explore the material basis of the difference of efficacy of Dahuang (Radix Et Rhizoma Rhei Palmati)-Taoren (Semen Persicae) (DT) drugs with different proportions.
Methods: Samples of different ratios of Dahuang (Radix et Rhizoma Rhei Palnati, DH) to Taoren (Semen Persicae, TR) (Group A 1:1, B 2:3, C 3:2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.
Results: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid (phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway.
Conclusion: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1:1.
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