洞察尾状两栖动物皮肤分泌物,重点关注衍生肽的化学性质和生物活性。

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lorena Kröner, Stefan Lötters, Marie-T Hopp
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引用次数: 0

摘要

众所周知,两栖动物能够在特化的皮肤腺体中产生和分泌生物活性物质的混合物,以达到抗生素自我保护和抵御天敌的目的。其中一些分泌物含有各种小分子物质,如剧毒的蝙蝠毒素、河豚毒素和翅果毒素。一段时间以来,两栖动物皮肤分泌物中的多肽一直吸引着研究人员,这些多肽由多种多样的序列组成--就目前所知--从 3 个氨基酸到 104 个氨基酸不等。在这 2000 多种肽中,许多都具有抗菌作用。此外,还有一些关于两栖动物皮肤肽的报道,这些肽可以促进伤口愈合、调节免疫反应,还可以作为抗寄生虫和抗氧化物质。迄今为止,研究重点主要集中在青蛙和蟾蜍(Anura)的皮肤肽上,而对约 700 种蝾螈和蝾螈的皮肤肽的研究则黯然失色。700 种蝾螈和蝾螈(尾目)皮肤肽的研究黯然失色。就在最近,有关尾状肢肽及其结构与功能关系的一些新发现被报道出来。本综述将重点介绍尾两栖动物皮肤肽的化学性质和生物活性,以及它们作为临床应用新型药物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights into caudate amphibian skin secretions with a focus on the chemistry and bioactivity of derived peptides.

Amphibians are well-known for their ability to produce and secrete a mixture of bioactive substances in specialized skin glands for the purpose of antibiotic self-protection and defense against predators. Some of these secretions contain various small molecules, such as the highly toxic batrachotoxin, tetrodotoxin, and samandarine. For some time, the presence of peptides in amphibian skin secretions has attracted researchers, consisting of a diverse collection of - to the current state of knowledge - three to 104 amino acid long sequences. From these more than 2000 peptides many are known to exert antimicrobial effects. In addition, there are some reports on amphibian skin peptides that can promote wound healing, regulate immunoreactions, and may serve as antiparasitic and antioxidative substances. So far, the focus has mainly been on skin peptides from frogs and toads (Anura), eclipsing the research on skin peptides of the ca. 700 salamanders and newts (Caudata). Just recently, several novel observations dealing with caudate peptides and their structure-function relationships were reported. This review focuses on the chemistry and bioactivity of caudate amphibian skin peptides and their potential as novel agents for clinical applications.

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来源期刊
Biological Chemistry
Biological Chemistry 生物-生化与分子生物学
CiteScore
7.20
自引率
0.00%
发文量
63
审稿时长
4-8 weeks
期刊介绍: Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.
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