{"title":"检测与蛋白质结合的小分子化合物","authors":"Haoran XU, Hui WANG, Yuanjing ZHAO, Weiquan ZHAN, Simin CHEN, Ping WANG","doi":"10.1016/j.cjac.2024.100398","DOIUrl":null,"url":null,"abstract":"<div><p>Protein-small molecule interactions play an important role in the life activities of organisms. Since protein/small molecule interactions are important for elucidating the diverse uses and their mechanisms in the fields of biological life multiplicity, disease cure, drug development, etc., methods to accurately detect protein/small molecule interactions have attracted much attention. This paper reviews the recent advances in interaction detection methods based on optical, thermodynamic, chromatographic and other principles. The structural types of small molecules for which the methods are mainly suitable and the principles of method selection are discussed, and the prospects for the combined application of different methods in the field of complex small molecule drugs are also envisaged.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 6","pages":"Article 100398"},"PeriodicalIF":1.2000,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204024000434/pdfft?md5=f99a30b9ada1da8a4ae68ff3bbff9a88&pid=1-s2.0-S1872204024000434-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Detection of small molecule compounds bound to proteins\",\"authors\":\"Haoran XU, Hui WANG, Yuanjing ZHAO, Weiquan ZHAN, Simin CHEN, Ping WANG\",\"doi\":\"10.1016/j.cjac.2024.100398\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Protein-small molecule interactions play an important role in the life activities of organisms. Since protein/small molecule interactions are important for elucidating the diverse uses and their mechanisms in the fields of biological life multiplicity, disease cure, drug development, etc., methods to accurately detect protein/small molecule interactions have attracted much attention. This paper reviews the recent advances in interaction detection methods based on optical, thermodynamic, chromatographic and other principles. The structural types of small molecules for which the methods are mainly suitable and the principles of method selection are discussed, and the prospects for the combined application of different methods in the field of complex small molecule drugs are also envisaged.</p></div>\",\"PeriodicalId\":277,\"journal\":{\"name\":\"Chinese Journal of Analytical Chemistry\",\"volume\":\"52 6\",\"pages\":\"Article 100398\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1872204024000434/pdfft?md5=f99a30b9ada1da8a4ae68ff3bbff9a88&pid=1-s2.0-S1872204024000434-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Analytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1872204024000434\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1872204024000434","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Detection of small molecule compounds bound to proteins
Protein-small molecule interactions play an important role in the life activities of organisms. Since protein/small molecule interactions are important for elucidating the diverse uses and their mechanisms in the fields of biological life multiplicity, disease cure, drug development, etc., methods to accurately detect protein/small molecule interactions have attracted much attention. This paper reviews the recent advances in interaction detection methods based on optical, thermodynamic, chromatographic and other principles. The structural types of small molecules for which the methods are mainly suitable and the principles of method selection are discussed, and the prospects for the combined application of different methods in the field of complex small molecule drugs are also envisaged.
期刊介绍：
Chinese Journal of Analytical Chemistry(CJAC) is an academic journal of analytical chemistry established in 1972 and sponsored by the Chinese Chemical Society and Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Its objectives are to report the original scientific research achievements and review the recent development of analytical chemistry in all areas. The journal sets up 5 columns including Research Papers, Research Notes, Experimental Technique and Instrument, Review and Progress and Summary Accounts. The journal published monthly in Chinese language. A detailed abstract, keywords and the titles of figures and tables are provided in English, except column of Summary Accounts. Prof. Wang Erkang, an outstanding analytical chemist, academician of Chinese Academy of Sciences & Third World Academy of Sciences, holds the post of the Editor-in-chief.
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