接触系统对心血管疾病的影响

Health Sciences Pub Date : 2024-05-01 DOI:10.35988/sm-hs.2024.126

Julija Valaitienė

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引用次数: 0

摘要

接触和内在凝血途径成分参与了病理性血栓的形成。除凝血外，接触系统的激活还参与了抗/纤溶和炎症过程，这些过程可促成动脉粥样硬化和血栓形成环境，导致心血管疾病。这篇文献综述涉及接触系统对心血管疾病的作用，并强调了凝血因子 FXII（FXII）和 FXI（FXI）作为抗血栓治疗靶点的潜力。

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IMPACT OF CONTACT SYSTEM ON CARDIOVASCULAR DISEASES

Contact and intrinsic coagulation pathway components are involved in pathological thrombus formation. In addition to coagulation, contact system activation is involved in anti/profibrinolytic and inflammatory processes that can contribute to the atherosclerotic and thrombotic environment, leading to cardiovascular diseases. This literature review concerns the role of the contact system on cardiovascular diseases and accentuates the potential of coagulation factors FXII (FXII) and FXI (FXI) as targets for antithrombotic therapy.

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Health Sciences

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