细胞外囊泡在胰腺癌中的潜在临床应用:从生物标记物到新型治疗方法,探索尚未开发的机会

Jose Manuel Sanchez-Manas, Natalia Perez de Gracia, S. Perales, Joaquina Martínez-Galán, Carolina Torres, Pedro J. Real
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引用次数: 0

摘要

胰腺癌是一种致死率很高的转移性恶性肿瘤,主要原因是由于目前诊断方法的局限性,胰腺癌往往在晚期才被发现,导致目前可用的疗法无效。因此,为胰腺癌的早期诊断和新的治疗靶点确定有用的生物标志物势在必行。最近,细胞外囊泡已成为诊断和预后胰腺癌的有前途的生物标志物。由于细胞外囊泡存在于各种体液中,因此可通过液体活检提供一种非侵入性的方法来检测和监测癌症进展。在这篇综述中,我们全面研究了细胞外囊泡在癌症进展中的多方面作用,同时还探讨了它们作为胰腺癌诊断、预后和治疗生物标记物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential clinical applications of extracellular vesicles in pancreatic cancer: exploring untapped opportunities from biomarkers to novel therapeutic approaches
Pancreatic cancer is a highly lethal and metastatic malignancy, mainly because it often remains undetected until advanced stages due to the limitations of current diagnostic methods, rendering currently available therapies ineffective. Therefore, it is imperative to identify useful biomarkers for early diagnosis and new therapeutic targets for pancreatic cancer. Recently, extracellular vesicles have emerged as promising biomarkers for the diagnosis and prognosis of pancreatic cancer. Given their presence in various bodily fluids, extracellular vesicles offer a non-invasive approach through liquid biopsy to detect and monitor cancer progression. In this review, we comprehensively examine the multifaceted roles of extracellular vesicles in the progression of cancer, while also exploring their potential as diagnostic, prognostic, and therapeutic biomarkers in the context of pancreatic cancer.
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