磁性氧化石墨烯上的生物相容性 O-羧甲基壳聚糖/丙烯酸共聚物,用于在离子监测-气相色谱/质谱法之前测定尿液中的儿茶素含量

IF 1.3 Q4 CHEMISTRY, ANALYTICAL
Golnaz Golmohammadi, H. Sereshti, S. Samadi, H. Rashidi Nodeh
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引用次数: 0

摘要

儿茶素是一种具有抗氧化特性的强效类黄酮,对于保护人体免受自由基侵害和促进整体健康至关重要。研究表明,尿液中含有儿茶素与降低罹患胃癌和食道癌的风险有关。本研究介绍了一种创新方法,即使用一种新型纳米复合材料从人体尿液中提取儿茶素,该材料由涂有生物相容性 O-羧甲基壳聚糖/丙烯酸共聚物的磁性氧化石墨烯组成。然后利用气相色谱/质谱-选择离子监测分析法对提取的儿茶素进行分析。在最佳条件下,儿茶素和表儿茶素的线性动态范围为0.5-1000 纳克/毫升,R2 为 0.9991;检测限等于 0.1 纳克/毫升;相对标准偏差分别为 4.1 和 3.1(0.5-1000 纳克/毫升):相对标准偏差分别为 4.1 和 3.1(C = 50 ng/mL,n = 3);相对回收率分别为 94%。该方法的应用为推进临床和毒理学研究以及建立饮茶与疾病预防之间的潜在联系带来了重大希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A biocompatible O‐carboxymethyl chitosan/acrylic acid copolymer over magnetic graphene oxide used for determination of catechins in urine prior to ion monitoring‐gas chromatography/mass spectrometry
Catechins, as powerful flavonoids with antioxidant properties, are crucial for the preservation of the human body against free radicals and for promoting overall health. Research has shown that the presence of catechins in urine is linked to a reduced risk of gastric and esophageal cancer. This study introduces an innovative approach using a novel nano‐composite material, composed of magnetic graphene oxide coated with a biocompatible O‐carboxymethyl chitosan/acrylic acid copolymer, for extracting catechins from human urine. The extracted catechins were then analyzed using gas chromatography/mass spectrometry‐selected ion monitoring analysis. Under the optimum conditions, the analytical figures of merit for catechin and epicatechin were linear dynamic range: 0.5–1000 ng/mL, R2 of 0.9991; limit of detection equal to 0.1 ng/mL; relative standard deviation: 4.1 and 3.1 (C = 50 ng/mL, n = 3); and relative recovery was 94%, respectively. The application of this method holds significant promise for advancing clinical and toxicological studies, as well as establishing potential associations between tea consumption and disease prevention.
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来源期刊
SEPARATION SCIENCE PLUS
SEPARATION SCIENCE PLUS CHEMISTRY, ANALYTICAL-
CiteScore
1.90
自引率
9.10%
发文量
111
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