罕见的皮肤病是播散性光化浅层角化病

Svetlana N. Schava, Marina A. Shishkina
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引用次数: 0

摘要

角化病是一类非常罕见的皮肤病,有获得性和遗传性之分,病因不明,以角化障碍为特征。该病表现为一个或多个萎缩斑,每个萎缩斑周围都有一个被称为 "角质板 "的特征性角化过度的脊状边缘。这种病症有多种形式,其中既有散发性病例,也有常染色体显性遗传的家族变异型,具有不同的渗透性。本文介绍了一个临床病例,一名 59 岁的妇女在长期暴露于阳光下后出现了浅表播散性光化性角化病。糜烂表现为小斑点,圆形,呈粉黄褐色,中心萎缩,周围有凸起的窄辊,表面有凹槽,无融合趋势,对称排列。筛查导致免疫抑制的疾病(人类免疫缺陷病毒、血液恶性肿瘤)和肾功能不全,均未发现病变。组织学检查显示有典型的局限性角化不全细胞(角板)、角化不全细胞、角化不良细胞或空泡化角质细胞,因此可以做出最终诊断。考虑到本病例中日照是一个重要的致病因素,而且在皮肤病的背景下发生恶性肿瘤的可能性仍然存在,因此,作为综合治疗的一部分,使用具有高度防护功能的防晒霜以及定期进行皮肤检查对这类患者来说极为重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rare dermatosis is disseminated actinic superficial porokeratosis
Porokeratoses are a very rare group of dermatoses, acquired or hereditary, of unknown etiology, characterized by a violation of keratinization. The disease is manifested by one or more atrophic spots, each of which is surrounded by a characteristic hyperkeratotic, ridge-like border called a "horny plate". There are several forms of this pathology, among which there are sporadic cases and family variants with an autosomal dominant pattern of inheritance of various penetrance. This article presents a clinical case of the occurrence of superficial disseminated actinic porokeratosis in a 59-year-old woman after prolonged exposure to the sun. The eruptions were represented by small spots, rounded, pinkish-yellow-brown in color with an atrophic center, surrounded by a raised narrow roller with a groove on the surface, have no tendency to merge, symmetrically arranged. Screening for diseases that cause immunosuppression (human immunodeficiency virus, hematological malignancies) and renal insufficiency did not reveal pathology. Histological examination showed a typical well-limited plume of parakeratotic cells (horn plate), hypogranulosis, dyskeratotic cells or vacuolated keratinocytes, which made it possible to make a final diagnosis. Considering that insolation in this case is a causally significant factor and the likelihood of malignant neoplasms against the background of dermatosis remains, it is extremely important for such patients to use sunscreens with a high degree of protection as part of complex therapy, as well as regular skin examinations.
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