聚焦超声作为胶质瘤的一种治疗方式

D. Nwafor, Derrick Obiri-Yeboah, Faraz Fazad, William Blanks, Melike Mut
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引用次数: 0

摘要

超声波最初被用作诊断工具,可在床边提供对多种病症(如胆结石、腹水、气胸等)的重要见解。近十年来,随着技术的进步,超声波已被用于治疗许多神经系统疾病,如本质性震颤和帕金森病,而且特异性很高。在避开周围组织的同时将超声波汇聚到特定的感兴趣区域/目标,这就是 "聚焦超声(FUS)"的由来。在肿瘤研究中,超声技术最初被用作肿瘤切除术的术中引导工具。然而,近年来,人们对利用 FUS 作为脑肿瘤(如胶质瘤)的治疗工具越来越感兴趣。这篇微型综述重点介绍了目前将 FUS 用作胶质瘤治疗方法的相关知识。此外,我们还讨论了 FUS 在增强中枢神经系统 (CNS) 药物输送方面的效用,并重点介绍了利用 FUS 作为胶质瘤治疗方式的前景看好的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Focused ultrasound as a treatment modality for gliomas
Ultrasound waves were initially used as a diagnostic tool that provided critical insights into several pathological conditions (e.g., gallstones, ascites, pneumothorax, etc.) at the bedside. Over the past decade, advancements in technology have led to the use of ultrasound waves in treating many neurological conditions, such as essential tremor and Parkinson’s disease, with high specificity. The convergence of ultrasound waves at a specific region of interest/target while avoiding surrounding tissue has led to the coined term “focused ultrasound (FUS).” In tumor research, ultrasound technology was initially used as an intraoperative guidance tool for tumor resection. However, in recent years, there has been growing interest in utilizing FUS as a therapeutic tool in the management of brain tumors such as gliomas. This mini-review highlights the current knowledge surrounding using FUS as a treatment modality for gliomas. Furthermore, we discuss the utility of FUS in enhanced drug delivery to the central nervous system (CNS) and highlight promising clinical trials that utilize FUS as a treatment modality for gliomas.
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