透明质酸相互作用分子介导了从原发肿瘤到远处转移的癌细胞与微环境之间的相互影响

Cancers Pub Date : 2024-05-16 DOI:10.3390/cancers16101907
Yali Xu, Johannes Benedikt, Lin Ye
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引用次数: 0

摘要

透明质酸(HA)是细胞外基质的重要组成部分,它与HA相互作用分子(HAIMs)的相互作用在癌症的发生和发展中起着至关重要的作用。这篇综述探讨了 HAIMs 在癌症中的多方面作用,通过剖析肿瘤细胞和肿瘤微环境中的相关细胞和分子机制,重点关注 HAIMs 对疾病进展的影响。HA 和 HAIMs 之间的相互作用会对癌症的进展产生深远影响。它们会调节细胞粘附、迁移、侵袭和增殖等关键过程。TME是一个动态平台,其中的HAIMs有助于形成独特的龛位。由此产生的 HA 成分变化深刻影响着 TME 的生物物理特性。TME 中的这些变化与 HAIMs 一起影响血管生成、免疫细胞招募和免疫逃避。因此,了解癌症背景下 HAIMs 与 HA 之间错综复杂的相互作用对于开发新型治疗策略至关重要。以这些相互作用为靶点为癌症治疗提供了前景广阔的途径,因为它们有可能破坏疾病进展和TME的关键环节。为了增进我们对癌症的了解和治疗,必须在这一领域开展进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyaluronic Acid Interacting Molecules Mediated Crosstalk between Cancer Cells and Microenvironment from Primary Tumour to Distant Metastasis
Hyaluronic acid (HA) is a prominent component of the extracellular matrix, and its interactions with HA-interacting molecules (HAIMs) play a critical role in cancer development and disease progression. This review explores the multifaceted role of HAIMs in the context of cancer, focusing on their influence on disease progression by dissecting relevant cellular and molecular mechanisms in tumour cells and the tumour microenvironment. Cancer progression can be profoundly affected by the interactions between HA and HAIMs. They modulate critical processes such as cell adhesion, migration, invasion, and proliferation. The TME serves as a dynamic platform in which HAIMs contribute to the formation of a unique niche. The resulting changes in HA composition profoundly influence the biophysical properties of the TME. These modifications in the TME, in conjunction with HAIMs, impact angiogenesis, immune cell recruitment, and immune evasion. Therefore, understanding the intricate interplay between HAIMs and HA within the cancer context is essential for developing novel therapeutic strategies. Targeting these interactions offers promising avenues for cancer treatment, as they hold the potential to disrupt critical aspects of disease progression and the TME. Further research in this field is imperative for advancing our knowledge and the treatment of cancer.
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