直接比较人和仓鼠血清中的 SARS-CoV-2 变异特异性中和抗体

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2024-05-18 DOI:10.1038/s41541-024-00888-y

Annika Rössler, Antonia Netzl, Ludwig Knabl, Samuel H Wilks, Barbara Mühlemann, Sina Türeli, Anna Mykytyn, Dorothee von Laer, Bart L Haagmans, Derek J Smith, Janine Kimpel

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引用次数: 0

摘要

新出现的 SARS-CoV-2 变体的抗原特征对于评估其免疫逃逸和判断未来疫苗更新的必要性非常重要。为了将从动物血清中获得的数据与人类血清相联系，我们在一个高度受控的环境中，使用一个实验室进行的相同的真实病毒中和试验，分析了人类和仓鼠单次感染血清中的中和抗体滴度。利用贝叶斯框架，我们发现仓鼠血清中的滴度折叠变化与人类血清十分吻合，而且仓鼠血清通常表现出更高的反应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera.

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Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera.

Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.