为轴突分支踩刹车

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-05-16 DOI:10.1016/j.tins.2024.05.001

Ismael Ferrer, Chadni Sanyal, Marie-Jo Moutin, Damaris N Lorenzo

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引用次数: 0

摘要

在最近的一项研究中，Ziak 等人利用精确的稀疏标记和时空控制的遗传操作，发现了小鼠第 2/3 层胼胝体投射神经元轴突分支的新型调控因子。作者阐明了一条细胞自主信号通路，在这条通路中，糖原合酶激酶 3β (GSK3β) 磷酸化微管相关蛋白 1B (MAP1B)，通过调节微管 (MT) 酪氨酸化状态来限制间隙轴突分支。

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Putting the brakes on axonal branching.

In a recent study, Ziak et al. employed precise sparse labeling and spatiotemporally controlled genetic manipulations to uncover novel regulators of axon branching of layer 2/3 mouse callosal projection neurons. The authors elucidated a cell-autonomous signaling pathway wherein glycogen synthase kinase 3β (GSK3β) phosphorylation of microtubule-associated protein 1B (MAP1B) restricts interstitial axon branching by modulating microtubule (MT) tyrosination status.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.