吡唑范例:揭示合成途径和抗癌潜力。

IF 1.9 4区 医学 Q3 CHEMISTRY, MEDICINAL
Poonam Kumari, Neetu Agrawal, Somdutt Mujwar
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引用次数: 0

摘要

本综述探讨了吡唑化合物的合成方法和抗癌活性。各种合成方法,包括传统的有机合成和微波辅助合成,都被用来改变吡唑的核心结构,从而产生具有更好药理特性的新化合物。论文还介绍了吡唑衍生物抗癌特性的作用机制,重点是与癌症生长和增殖相关的主要分子靶点的相互作用。SAR 见解有助于合理开发新型抗癌药物。总之,综述强调了吡唑衍生物作为发现和开发新型抗癌药物支架的多功能性。通过了解合成路线和揭示抗癌潜力,本研究希望鼓励新的研究工作,重点利用吡唑范例的治疗优势来抗击癌症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pyrazole Paradigms: Unveiling Synthetic Pathways and Unraveling Anti-Cancer Potential.

This review investigates the synthetic methods and anti-cancer activities of pyrazole compounds. Various synthetic approaches, including traditional organic synthesis and microwaveassisted synthesis, have been used to change the pyrazole core structure, resulting in new compounds with improved pharmacological properties. The paper also covers the mechanisms of action that underpin pyrazole derivatives' anti-cancer characteristics, focusing on interactions with major molecular targets implicated in cancer growth and proliferation. SAR insights help to rationally develop novel anti-cancer drugs. In conclusion, the review emphasizes the versatility of pyrazole derivatives as scaffolds for the discovery and development of new anti-cancer medicines. By understanding synthesis routes and unravelling anti-cancer potential, this study hopes to encourage new research endeavours focused on leveraging the therapeutic advantages of pyrazole paradigms in the fight against cancer.

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来源期刊
Medicinal Chemistry
Medicinal Chemistry 医学-医药化学
CiteScore
4.30
自引率
4.30%
发文量
109
审稿时长
12 months
期刊介绍: Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.
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