释放抗体的力量:明日疗法工程

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Sagar, Malemnganba Takhellambam, Aditi Rattan, Vijay Kumar Prajapati
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引用次数: 0

摘要

抗体在宿主抵御各种疾病的过程中发挥着至关重要的作用。抗体工程是一个多学科领域,旨在提高人类的生活质量。在疾病方面,抗体是高度特化的蛋白质,是抵御病原体及其引起的疾病的重要防线。这些感染通过呈现在树突状细胞等抗原呈递细胞上,触发先天性免疫。这最终会与适应性免疫相联系,在适应性免疫中,针对特定抗原的抗体会产生并成熟。抗体与特定抗原结合后,会触发各种免疫反应,在一个称为补体依赖性细胞毒性的过程中消灭病原体,免疫细胞吞噬入侵微生物或诱导抗体依赖性细胞毒性都是由抗体完成的。这些工程抗体被用于治疗、诊断和生物技术研究等多种用途。包括杂交瘤技术、转基因小鼠、噬菌体、酵母和核糖体展示等展示技术以及下一代测序在内的尖端技术是设计抗体并大量生产供人类使用的途径。考虑到抗体在保护人们免受各种病原体侵害方面的重要性,投资研究为开发未来的治疗靶点以防治各种疾病带来了巨大希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unleashing the power of antibodies: Engineering for tomorrow's therapy.

Antibodies play a crucial role in host defense against various diseases. Antibody engineering is a multidisciplinary field that seeks to improve the quality of life of humans. In the context of disease, antibodies are highly specialized proteins that form a critical line of defense against pathogens and the disease caused by them. These infections trigger the innate arm of immunity by presenting on antigen-presenting cells such as dendritic cells. This ultimately links to the adaptive arm, where antibody production and maturation occur against that particular antigen. Upon binding with their specific antigens, antibodies trigger various immune responses to eliminate pathogens in a process called complement-dependent cytotoxicity and phagocytosis of invading microorganisms by immune cells or induce antibody-dependent cellular cytotoxicity is done by antibodies. These engineered antibodies are being used for various purposes, such as therapeutics, diagnostics, and biotechnology research. Cutting-edge techniques that include hybridoma technology, transgenic mice, display techniques like phage, yeast and ribosome displays, and next-generation sequencing are ways to engineer antibodies and mass production for the use of humankind. Considering the importance of antibodies in protecting from a diverse array of pathogens, investing in research holds great promise to develop future therapeutic targets to combat various diseases.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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