MHC 四聚体技术:探索健康和疾病中的 T 细胞生物学。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Rahul Tiwari, Vishal Kumar Singh, Rajneesh, Awnish Kumar, Vibhav Gautam, Rajiv Kumar
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引用次数: 0

摘要

主要组织相容性复合体(MHC)四聚体是 T 细胞生物学中的强大工具,有助于探索和理解免疫反应。这些人工分子由四个结合的 MHC 分子组成,通常带有一个特定的肽和一个荧光标签,在描述 T 细胞亚群特征、监测克隆扩增以及揭示 T 细胞对感染或免疫疗法反应过程中的动态变化方面发挥着关键作用。除了在 T 细胞生物学中的应用,MHC 四聚体在研究传染病、自身免疫性疾病和癌症等一系列疾病方面也很有价值。它们在疫苗研发中也发挥着重要作用。值得注意的是,如果配置得当,四聚体将超越 T 细胞生物学研究,在探索自然杀伤 T 细胞和促进特定 T 细胞克隆缺失方面发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MHC tetramer technology: Exploring T cell biology in health and disease.

Major histocompatibility complex (MHC) tetramers stand as formidable tools within T cell biology, facilitating the exploration and comprehension of immune responses. These artificial molecules, comprising four bound MHC molecules, typically with a specified peptide and a fluorescent label, play a pivotal role in characterizing T cell subsets, monitoring clonal expansion, and unraveling T cell dynamics during responses to infections or immunotherapies. Beyond their applications in T cell biology, MHC tetramers prove valuable in investigating a spectrum of diseases such as infectious diseases, autoimmune disorders, and cancers. Their instrumental role extends to vaccine research and development. Notably, when appropriately configured, tetramers transcend T cell biology research and find utility in exploring natural killer T cells and contributing to specific T cell clonal deletions.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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