柿石姬毛蛛子实体中乌斯塔酸空间分布的可视化。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-05-18 DOI:10.1007/s11418-024-01823-0

Tetsuro Ito, Syu Taira, Wataru Aoki, Hiroyuki Nagai, Masashi Fukaya, Kaori Ryu, Akiyoshi Yamada

{"title":"柿石姬毛蛛子实体中乌斯塔酸空间分布的可视化。","authors":"Tetsuro Ito, Syu Taira, Wataru Aoki, Hiroyuki Nagai, Masashi Fukaya, Kaori Ryu, Akiyoshi Yamada","doi":"10.1007/s11418-024-01823-0","DOIUrl":null,"url":null,"abstract":"<div><p>Imaging mass spectrometry (IMS) was conducted for the first time using ustalic acid (UA) and the fruiting body of <i>Tricholoma kakishimeji</i> to localize mushroom toxins. The mushroom materials were systematically collected in Japan, and analysis of the cross sections of the materials at a resolution of 120 μm using matrix-assisted laser desorption/ionization mass spectrometry (MALDI–IMS) revealed the localization of UA and its biogenically related metabolites. MALDI–IMS confirmed that UA was predominantly located on the entire surface of the fruiting body and accumulated in higher amounts in younger fruiting bodies than in mature ones. UA is the first toxic secondary metabolite in the genus <i>Tricholoma</i> locally identified using IMS in mushrooms.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"78 4","pages":"838 - 843"},"PeriodicalIF":2.5000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji\",\"authors\":\"Tetsuro Ito, Syu Taira, Wataru Aoki, Hiroyuki Nagai, Masashi Fukaya, Kaori Ryu, Akiyoshi Yamada\",\"doi\":\"10.1007/s11418-024-01823-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Imaging mass spectrometry (IMS) was conducted for the first time using ustalic acid (UA) and the fruiting body of <i>Tricholoma kakishimeji</i> to localize mushroom toxins. The mushroom materials were systematically collected in Japan, and analysis of the cross sections of the materials at a resolution of 120 μm using matrix-assisted laser desorption/ionization mass spectrometry (MALDI–IMS) revealed the localization of UA and its biogenically related metabolites. MALDI–IMS confirmed that UA was predominantly located on the entire surface of the fruiting body and accumulated in higher amounts in younger fruiting bodies than in mature ones. UA is the first toxic secondary metabolite in the genus <i>Tricholoma</i> locally identified using IMS in mushrooms.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":654,\"journal\":{\"name\":\"Journal of Natural Medicines\",\"volume\":\"78 4\",\"pages\":\"838 - 843\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-05-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11418-024-01823-0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11418-024-01823-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

首次使用宇ustalic 酸（UA）和柿石姬菇子实体进行了成像质谱（IMS）分析，以确定蘑菇毒素的位置。这些蘑菇材料是在日本系统收集的，使用基质辅助激光解吸/电离质谱（MALDI-IMS）以 120 μm 的分辨率对材料的横截面进行分析，发现了 UA 及其生物相关代谢物的定位。MALDI-IMS 证实，UA 主要分布在子实体的整个表面，在幼嫩子实体中的积累量高于成熟子实体。UA 是当地利用 IMS 在蘑菇中鉴定出的 Tricholoma 属中的首个有毒次级代谢物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji

查看原文本刊更多论文

Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji

Imaging mass spectrometry (IMS) was conducted for the first time using ustalic acid (UA) and the fruiting body of Tricholoma kakishimeji to localize mushroom toxins. The mushroom materials were systematically collected in Japan, and analysis of the cross sections of the materials at a resolution of 120 μm using matrix-assisted laser desorption/ionization mass spectrometry (MALDI–IMS) revealed the localization of UA and its biogenically related metabolites. MALDI–IMS confirmed that UA was predominantly located on the entire surface of the fruiting body and accumulated in higher amounts in younger fruiting bodies than in mature ones. UA is the first toxic secondary metabolite in the genus Tricholoma locally identified using IMS in mushrooms.

Graphical abstract

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.