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引用次数: 0
摘要
尽管线粒体是细胞能量需求的中心,但考虑每个细胞如何调整其线粒体组成和功能以适应其 ATP 生产以外的特殊需求正变得越来越重要。在此,我们将深入探讨线粒体在整个发育过程中的异质性以及在具有特定能量需求的组织中的异质性,并讨论线粒体的可塑性如何有助于细胞命运的决定和组织的重塑。Granath-Panelo 和 Kajimura 回顾了不同情况下线粒体异质性的新证据,并讨论了线粒体的可塑性如何有助于细胞命运决定和组织重塑。
Mitochondrial heterogeneity and adaptations to cellular needs
Although it is well described that mitochondria are at the epicentre of the energy demands of a cell, it is becoming important to consider how each cell tailors its mitochondrial composition and functions to suit its particular needs beyond ATP production. Here we provide insight into mitochondrial heterogeneity throughout development as well as in tissues with specific energy demands and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling. Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling.
期刊介绍:
Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to:
-Autophagy
-Cancer biology
-Cell adhesion and migration
-Cell cycle and growth
-Cell death
-Chromatin and epigenetics
-Cytoskeletal dynamics
-Developmental biology
-DNA replication and repair
-Mechanisms of human disease
-Mechanobiology
-Membrane traffic and dynamics
-Metabolism
-Nuclear organization and dynamics
-Organelle biology
-Proteolysis and quality control
-RNA biology
-Signal transduction
-Stem cell biology