两名肉毒杆菌-A 肌肉注射后肉毒杆菌样综合征患者的神经肌肉传导电生理异常

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2024-05-17 DOI:10.1016/j.neucli.2024.102984

Julian Theuriet , Laure Huchon , Jacques Luaute , Anne-Evelyne Vallet , Françoise Bouhour , Antoine Pegat

{"title":"两名肉毒杆菌-A 肌肉注射后肉毒杆菌样综合征患者的神经肌肉传导电生理异常","authors":"Julian Theuriet , Laure Huchon , Jacques Luaute , Anne-Evelyne Vallet , Françoise Bouhour , Antoine Pegat","doi":"10.1016/j.neucli.2024.102984","DOIUrl":null,"url":null,"abstract":"<div><p>Botulinum neurotoxin serotype A (BoNT-A) has several therapeutic indications such as spasticity and dystonia. Although its use is generally considered safe, a systemic diffusion can lead to systemic complications, and a botulism-like syndrome can occur after intramuscular injections. Herein, two adult cases who developed general muscle weakness after a BoNT-A intramuscular injection are reported. Both presented with a progressive decrement on low-frequency (LF) repetitive nerve stimulation (RNS). It is suggested that a progressive decrement on LF-RNS in muscles distant from the injection site strongly supports the diagnosis of iatrogenic botulism.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102984"},"PeriodicalIF":2.7000,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S098770532400042X/pdfft?md5=e10f627d148fa9d107b542b40cf1cdce&pid=1-s2.0-S098770532400042X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Electrophysiological abnormalities of the neuromuscular transmission in two patients with botulism-like syndrome following Botulinum-A muscle injections\",\"authors\":\"Julian Theuriet , Laure Huchon , Jacques Luaute , Anne-Evelyne Vallet , Françoise Bouhour , Antoine Pegat\",\"doi\":\"10.1016/j.neucli.2024.102984\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Botulinum neurotoxin serotype A (BoNT-A) has several therapeutic indications such as spasticity and dystonia. Although its use is generally considered safe, a systemic diffusion can lead to systemic complications, and a botulism-like syndrome can occur after intramuscular injections. Herein, two adult cases who developed general muscle weakness after a BoNT-A intramuscular injection are reported. Both presented with a progressive decrement on low-frequency (LF) repetitive nerve stimulation (RNS). It is suggested that a progressive decrement on LF-RNS in muscles distant from the injection site strongly supports the diagnosis of iatrogenic botulism.</p></div>\",\"PeriodicalId\":19134,\"journal\":{\"name\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"volume\":\"54 4\",\"pages\":\"Article 102984\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S098770532400042X/pdfft?md5=e10f627d148fa9d107b542b40cf1cdce&pid=1-s2.0-S098770532400042X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S098770532400042X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurophysiologie Clinique/Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S098770532400042X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

血清 A 型肉毒杆菌神经毒素（BoNT-A）具有多种治疗适应症，如痉挛和肌张力障碍。尽管人们普遍认为其使用是安全的，但全身扩散可能导致全身并发症，肌肉注射后可能出现肉毒中毒样综合征。本文报告了两例在肌肉注射 BoNT-A 后出现全身肌无力的成人病例。两人在接受低频（LF）重复神经刺激（RNS）后均出现进行性肌力下降。研究认为，远离注射部位的肌肉在接受低频重复神经刺激（LF-RNS）时出现进行性减弱，可有力地支持先天性肉毒中毒的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Electrophysiological abnormalities of the neuromuscular transmission in two patients with botulism-like syndrome following Botulinum-A muscle injections

Botulinum neurotoxin serotype A (BoNT-A) has several therapeutic indications such as spasticity and dystonia. Although its use is generally considered safe, a systemic diffusion can lead to systemic complications, and a botulism-like syndrome can occur after intramuscular injections. Herein, two adult cases who developed general muscle weakness after a BoNT-A intramuscular injection are reported. Both presented with a progressive decrement on low-frequency (LF) repetitive nerve stimulation (RNS). It is suggested that a progressive decrement on LF-RNS in muscles distant from the injection site strongly supports the diagnosis of iatrogenic botulism.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.