超越抑郁：有阿尔茨海默病风险的老年妇女的各种情绪症状与 Tau 病理学的关系。

IF 1.2 4区医学 Q3 GERONTOLOGY

International Journal of Aging & Human Development Pub Date : 2024-05-15 DOI:10.1177/00914150241253257

Nargis Ahmadi, Melanie A Dratva, Nadine Heyworth, Xin Wang, Kaj Blennow, Sarah J Banks, Erin E Sudermann

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引用次数: 0

摘要

我们研究了情绪范围内的症状与阿尔茨海默病（AD）高风险老年妇女的生物标志物之间的关系。研究对象包括 25 名 65 岁以上、有轻度认知障碍且阿尔茨海默病遗传风险较高的女性。情绪状态概况问卷测量了情绪症状和情绪障碍总分。采用MK-6240 Tau正电子发射断层扫描（PET）成像技术测量了元颞区的Tau负荷。一部分患者（n = 12）还测量了血浆中 p-Tau181 和 Aß40/42 的水平。TMD 评分越高，tau PET 标准化摄取值比（SUVR）越高。更严重的负面情绪症状与更高的 tau PET SUVR 相关，而更强的活力与更低的 SUVR 相关。血浆p-Tau181水平也有类似结果，但Aβ40/42水平没有类似结果。总之，积极和消极情绪症状与注意力缺失症高风险老年妇女的tau病理相关，突出了心理健康在注意力缺失症风险中的作用。

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Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease.

We examined how symptoms across the mood spectrum relate to Alzheimer's disease (AD) biomarkers in older women at high risk for AD. Participants included 25 women aged 65+ with mild cognitive deficits and elevated AD genetic risk. The Profile of Mood States Questionnaire measured mood symptoms and a total mood disturbance (TMD) score. Tau burden in the meta-temporal region of interest was measured using MK-6240 Tau positron emission tomography (PET) imaging. A subset (n = 12) also had p-Tau181, and Aß40/42 levels measured in plasma. Higher TMD scores related to higher tau PET standardized uptake value ratio (SUVR). Greater negative mood symptoms correlated with higher tau PET SUVR, while greater vigor correlated with lower SUVR. Similar results were seen with plasma p-Tau181 levels, but not with Aβ40/42 levels. In conclusion, positive and negative mood symptoms related to tau pathology in older women at high risk for AD, highlighting a role of mental well-being in AD risk.

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来源期刊

International Journal of Aging & Human Development Multiple-

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： These are some of the broad questions with which the International Journal of Aging and Human Development is concerned. Emphasis is upon psychological and social studies of aging and the aged. However, the Journal also publishes research that introduces observations from other fields that illuminate the "human" side of gerontology, or utilizes gerontological observations to illuminate in other fields.