感染是克隆免疫球蛋白急性、一过性肾小球沉积的诱因。

IF 1.1 4区医学 Q4 MICROSCOPY

Ultrastructural Pathology Pub Date : 2024-07-03 Epub Date: 2024-05-16 DOI:10.1080/01913123.2024.2356112

Bangchen Wang, Micah Schub, Derrick L Robinson, David N Howell

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引用次数: 0

摘要

在瓦尔登斯特伦巨球蛋白血症（WM）和Ⅰ型低温球蛋白血症（CG）中可见到单克隆 IgM 在肾小球沉积，经常表现为毛细血管内假血栓。它们通常与浆细胞或 B 淋巴肿瘤有关，尤其是淋巴浆细胞性淋巴瘤（LPL）。虽然感染是混合型（II 型和 III 型）CG 的常见诱因，但感染与 I 型 CG 的关联并不常见。我们报告了两个病例，这两个病例在已知或疑似全身感染的情况下出现了惊人的λ-链限制性 IgM 沉积和急性肾损伤（AKI），并在治疗感染后迅速缓解。

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Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins.

Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.

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来源期刊

Ultrastructural Pathology 医学-病理学

CiteScore

2.00

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.