比较 308 纳米发光二极管和 308 纳米准分子灯治疗白癜风的疗效:随机对照试验。

IF 2.5 4区 医学 Q2 DERMATOLOGY
Yu Hu, Lihao Liu, Zhuohong Xu, Dan Huang, Hongying Chen, Jiaan Zhang, Lihao Chen, Xiaoxi Dai, Liangliang Zhang, Chao Luan, Mei Ju, Kun Chen
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引用次数: 0

摘要

背景:在以往的研究中,308纳米发光二极管(LED)已被证明对治疗白癜风安全有效。然而,308 纳米 LED 和 308 纳米准分子灯(308-nm MEL)在治疗白癜风方面还缺乏直接比较:比较 308 纳米 LED 和 308 纳米 MEL 治疗非节段性稳定期白癜风的疗效:这项随机对照试验于2018年1月至2023年8月期间进行。入组患者被随机分配到 308-nm LED 组或 308-nm MEL 组,均接受 16 次治疗。治疗期间发生的不良事件均有记录:共有 174 名患者的 269 个稳定期白癜风斑块完成了研究。308-nm LED 组共有 131 个皮损,308-nm MEL 组共有 138 个皮损。经过 16 次治疗后,308 纳米 LED 组有 38.17% 的白癜风斑块达到了至少 50% 的再色素沉着,而 308 纳米 MEL 组则为 38.41%。两种设备在色素恢复至少50%方面的疗效相似(p = 0.968)。两种光疗设备的不良反应发生率相当(p = .522):结论:308 纳米 LED 治疗白癜风的有效率与 308 纳米 MEL 相似,两种设备的不良反应发生率相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing the efficacy of 308-nm light-emitting diode and 308-nm excimer lamp for treating vitiligo: A randomized controlled trial.

Background: In previous studies, the 308-nm light-emitting diode (LED) has been proven safe and effective for treating vitiligo. However, direct comparisons between the 308-nm LED and 308-nm excimer lamp (308-nm MEL) for the treatment of vitiligo are lacking.

Objective: To compare the efficacy of the 308-nm LED and 308-nm MEL for treating nonsegmental stable vitiligo.

Patients and methods: This randomized controlled trial was conducted between January 2018 and August 2023. Enrolled patients were randomly assigned to either the 308-nm LED or the 308-nm MEL groups, both receiving 16 treatment sessions. Adverse events that occurred during the treatment were documented.

Results: In total, 269 stable vitiligo patches from 174 patients completed the study. A total of 131 lesions were included in the 308-nm LED group, and 138 lesions were included in the 308-nm MEL group. After 16 treatment sessions, 38.17% of the vitiligo patches in the 308-nm LED group achieved repigmentation of at least 50% versus 38.41% in the 308-nm MEL group. The two devices exhibited similar results in terms of efficacy for a repigmentation of at least 50% (p = .968). The incidence of adverse effects with the two phototherapy devices was comparable (p = .522).

Conclusions: Treatment of vitiligo with the 308-nm LED had a similar efficacy rate to the 308-nm MEL, and the incidence of adverse effects was comparable between the two devices.

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来源期刊
CiteScore
4.40
自引率
7.70%
发文量
85
审稿时长
6-12 weeks
期刊介绍: The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.
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