儿科人群中的持续性炎症、免疫抑制和分解代谢综合征:简述。

IF 1.3 Q3 PEDIATRICS
Michael D Santarelli, Kelly A Davis, Ryan J Stark
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引用次数: 0

摘要

由于医疗保健的进步,在败血症、创伤和大手术等濒临死亡的病症中幸存下来的情况越来越普遍。死亡率的下降掩盖了慢性重症患者的群体,其中许多人具有病理免疫表型,即持续炎症、免疫抑制和分解综合征(PICS)。虽然最初是在成人身上发现的,但许多重症儿童也表现出 PICS 的特征,包括淋巴细胞减少、炎症亢进和持续的体细胞蛋白质分解。这些患者受到反复感染的困扰,预后较差。目前仍有必要了解这一病症的病理生理学基础,以阐明潜在的疗法并开发干预措施。这一观点提供了儿科 PICS 的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Pediatric Populations: A Brief Perspective.

Surviving near-lethal insults, such as sepsis, trauma, and major surgery is more common due to advances in medical care. The decline in mortality has unmasked a population of chronic critically ill patients, many with the pathological immunophenotype known as Persistent inflammation, Immunosuppression, and Catabolism Syndrome (PICS). Though initially described in adults, many critically ill children exhibit the hallmarks of PICS, including lymphopenia, hyperinflammation, and evidence of ongoing somatic protein catabolism. These patients are plagued with recurrent infections and suffer worse outcomes. There remains a need to understand the pathophysiology underlying this condition to elucidate potential therapies and develop interventions. This perspective provides the most current update of PICS within the pediatric population.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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