一氧化氮和神经内分泌系统在疼痛产生中的作用。

IF 3.8 3区医学 Q2 CELL BIOLOGY

Molecular and Cellular Endocrinology Pub Date : 2024-05-14 DOI:10.1016/j.mce.2024.112270

Aayush Gupta , Maja Vejapi , Nebojsa Nick Knezevic

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引用次数: 0

摘要

以往的研究表明，一氧化氮（NO）疼痛信号通路与体内荷尔蒙信号通路之间存在复杂的相互作用。本文阐述了一氧化氮信号在神经性和炎症性疼痛产生中的作用，随后讨论了神经内分泌系统如何参与疼痛的产生。荷尔蒙系统包括下丘脑-垂体轴（HPA）产生的皮质醇、肾素-血管紧张素-醛固酮系统、降钙素、褪黑激素和性荷尔蒙，这些系统都有可能促进一氧化氮的产生，从而影响疼痛的感觉。有必要开展进一步的研究来澄清这种关系，并揭示涉及一氧化氮信号转导的治疗目标，以减轻神经性和炎症性疼痛。

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The role of nitric oxide and neuroendocrine system in pain generation

Previous studies have indicated a complex interplay between the nitric oxide (NO) pain signaling pathways and hormonal signaling pathways in the body. This article delineates the role of nitric oxide signaling in neuropathic and inflammatory pain generation and subsequently discusses how the neuroendocrine system is involved in pain generation. Hormonal systems including the hypothalamic-pituitary axis (HPA) generation of cortisol, the renin-angiotensin-aldosterone system, calcitonin, melatonin, and sex hormones could potentially contribute to the generation of nitric oxide involved in the sensation of pain. Further research is necessary to clarify this relationship and may reveal therapeutic targets involving NO signaling that alleviate neuropathic and inflammatory pain.

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.