柽柳属的植物化学和药理特性:全面综述。

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
Fangjie Li, Wenli Xie, Xianrui Ding, Kuo Xu, Xianjun Fu
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引用次数: 0

摘要

柽柳科柽柳属在全世界有 100 多种盐生植物,主要用于改良盐碱地、沿海防风林、固沙和干旱地区植树造林。该属植物中的相当多种类还被用作治疗各种人类疾病的传统药物,尤其是在亚洲和非洲国家。本综述全面总结了从柽柳属植物中提取的 655 种天然化合物,分为黄酮类(18.0%)、酚类(13.9%)、单宁类(9.3%)、萜类(10.5%)、精油类(31.0%)和其他类(17.3%)。调查显示,该属植物的粗提取物和植物化学物质具有显著的治疗潜力,包括抗炎、抗老年痴呆、抗癌、抗糖尿病、抗菌和抗真菌活性。六种柽柳具有抗癌作用,能导致癌细胞死亡、诱导自噬和停止细胞分裂。同属的 7 个物种有可能通过抑制α-糖苷酶活性、抑制人胰岛淀粉样多肽、调节血糖水平以及调节自噬或炎症来治疗糖尿病。抗菌和抗糖尿病作用之所以受到关注,是因为其中含有挥发油和类黄酮成分。目前已对 30 种成分的生物活性进行了广泛研究,其中包括 15 种黄酮类化合物、5 种酚类化合物、3 种萜类化合物、1 种单宁酸和 6 种其他成分。因此,未来的研究应深入研究这些和类似化合物的作用机制。这是关于柽柳植物化学和药理特性的最全面的综述,对目前的知识状况进行了批判性评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review

Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review

Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review

The genus Tamarix in the Tamaricaceae family consists of more than 100 species of halophyte plants worldwide that are mainly used to improve saline-alkali land and for coastal windbreaks, sand fixation, and afforestation in arid areas. A considerable number of species in this genus are also used as traditional medicines to treat various human diseases, especially in Asian and African countries. This review presents a comprehensive summary of 655 naturally occurring compounds derived from the genus Tamarix, categorized into flavonoids (18.0%), phenols (13.9%), tannins (9.3%), terpenoids (10.5%), essential oils (31.0%), and others (17.3%). The investigation revealed that the crude extracts and phytochemicals of this genus exhibited significant therapeutic potential, including anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, antibacterial, and antifungal activities. Six species of Tamarix have anticancer effects by causing cancer cell death, inducing autophagy, and stopping cell division. Seven species from the same genus have the potential for treating diabetes by inhibiting α-glycosidase activity, suppressing human islet amyloid polypeptide, regulating blood glucose levels, and modulating autophagy or inflammation. The focus on antibacterial and antidiabetic effects is due to the presence of volatile oil and flavonoid components. Extensive research has been conducted on the biological activity of 30 constituents, including 15 flavonoids, 5 phenols, 3 terpenoids, 1 tannin, and 6 others. Therefore, future research should thoroughly study the mechanisms of action of these and similar compounds. This is the most comprehensive review of the phytochemistry and pharmacological properties of Tamarix species, with a critical assessment of the current state of knowledge.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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