以不同疗程和给药途径提供可改变病情的阿尔茨海默氏症治疗的医疗成本和护理负担

IF 4.3 Q2 BUSINESS
T. Ozawa, G. Franguridi, Soeren Mattke
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引用次数: 0

摘要

背景目前有多种针对阿尔茨海默病的疾病调节疗法正在临床开发中,或已于近期获批使用。本研究旨在分析给药方式、治疗频率和持续时间以及监测要求如何影响疾病修饰治疗的价值。为了分离这些影响,我们比较了疗效和安全性相同的五种假定的疾病调整治疗方法:(1)慢性双周静脉输注;(2)慢性四周静脉输注;(3)52 周固定疗程四周静脉输注;(4)慢性皮下注射;(5)慢性口服处方,并对其直接医疗成本、护理人员负担和治疗价值进行了分析。结果 长期双周输液治疗的直接医疗成本(45208 美元)和护理人员负担(6095 美元)最高,治疗价值降低了 44%,而口服治疗的直接医疗成本(1983 美元)和护理人员负担(457 美元)最低,治疗价值仅降低了 2%。调查报告显示,护理人员负担沉重,据报告,平均每次就诊和输液时间为 2.3 小时,往返交通时间为 44 分钟,78% 的患者由护理人员陪同接受治疗。结果表明,有必要减少治疗的复杂性,减少就诊次数,以保持改变疾病治疗的经济价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Medical Costs and Caregiver Burden of Delivering Disease-Modifying Alzheimer’s Treatments with Different Duration and Route of Administration

Medical Costs and Caregiver Burden of Delivering Disease-Modifying Alzheimer’s Treatments with Different Duration and Route of Administration

Background

Multiple disease modifying treatment for Alzheimer’s disease are currently in clinical development or have been recently approved for use. They have vastly different treatment properties but so far, little work has been done to quantify the impact of treatment properties on the treatment’s value in terms of medical and social care costs and caregiver burden.

Objectives

This study aims to analyze how the mode of treatment administration, treatment frequency and duration, and monitoring requirements affect the value of disease modifying treatments. In order to isolate these effects, we compare five hypothetical disease modifying treatments with equal efficacy and safety: (1) chronic bi-weekly intravenous infusion, (2) chronic four-weekly intravenous infusion, (3) 52 weeks fixed duration four-weekly intravenous infusion, (4) chronic subcutaneous injections, and (5) chronic oral prescription on their direct medical costs, caregiver burden, and preservation of treatment value.

Design

Survey of Alzheimer’s disease treatment clinics and retrospective data analysis.

Setting

United States.

Measurements

Direct medical cost and caregiver burden of treatment administration and monitoring compared to gross treatment benefit.

Results

Chronic bi-weekly infusion treatment had the highest direct medical cost ($45,208) and caregiver burden ($6,095), reducing the treatment value by 44%, while oral treatment with the lowest direct medical cost ($1,983) and caregiver burden ($457) reduced the treatment value by only 2%. Substantial caregiver burden was reported from the survey, with a reported average of 2.3 hours for an office visit and infusion, 44 minutes of round-trip travel time, and 78% of patients being accompanied by a caregiver for treatment.

Conclusion

Burden of chronic intravenous treatments exceed the gross medical and social care cost savings and value of caregiver benefit. The results suggest the need for less complex treatments that require fewer clinic visits to preserve the economic value of disease modifying treatments.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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