缺血后条件和热休克蛋白 72 变化对无心绞痛前兆的急性心肌梗死患者的潜在影响

IF 1.2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Toshiharu Takeuchi, Yuya Kitani, Akiho Minoshima, Hisanobu Ota, Naoki Nakagawa, Kazuhiro Sumitomo, Yoshinao Ishii, Naoyuki Hasebe
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引用次数: 0

摘要

缺血后条件(iPoC)对未进行缺血预处理的 ST 段抬高型心肌梗死(STEMI)患者的有效性尚未确定。因此,我们研究了 iPoC 及其与热休克蛋白 72(HSP72)诱导相关的潜在机制对无前驱心绞痛(PA)的 STEMI 患者心肌救治的影响。我们回顾性分析了 323 例急性冠状动脉综合征连续患者中 102 例成功再灌注的 STEMI 患者的数据。其中,55 名 iPoC(iPoC (+) )患者接受了 4 个周期的血管成形术球囊充气 60 秒和放气 30 秒。iPoC (+) 组和 iPoC (-) 组又分为两个亚组:有 PA(PA (+) )和无 PA(PA (-) )的患者。我们对中性粒细胞中的 HSP72 水平进行了分析,直到再灌注后 48 小时。在再灌注治疗后一周内进行了 I-123 β-甲基-对碘苯基-十五烷酸(BMIPP)闪烁扫描。使用 BMIPP 和 TL,在 PA(-)亚组中,iPoC(+)组的心肌挽救率显著高于 iPoC(-)组。iPoC 被确定为心肌挽救率的独立预测因子。iPoC (+) PA (-) 组的 HSP72 增加比率明显升高。重要的是,无 PA 患者的心肌救治效果与 HSP72 升高比值显著相关,而 iPoC 患者的 HSP72 升高比值更高。这些结果表明,iPoC 通过 HSP72 诱导对心肌救治有潜在影响;但这种影响可能仅限于无 PA 的 STEMI 患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Effects of Ischemic Postconditioning and Changes in Heat Shock Protein 72 in Patients with Acute Myocardial Infarction without Prodromal Angina

The effectiveness of ischemic postconditioning (iPoC) in patients with ST-elevation myocardial infarction (STEMI) without ischemic preconditioning has not been determined. Therefore, we investigated the impact of iPoC and its potential mechanism related to heat shock protein 72 (HSP72) induction on myocardial salvage in patients with STEMI without prodromal angina (PA).

We retrospectively analyzed data from 102 patients with STEMI with successful reperfusion among 323 consecutive patients with acute coronary syndrome. Among these, 55 patients with iPoC (iPoC (+) ) underwent 4 cycles of 60-second inflation and 30-second deflation of the angioplasty balloon. Both the iPoC (+) and iPoC (-) groups were divided into 2 further subgroups: patients with PA (PA (+) ) and those without (PA (-) ). We analyzed HSP72 levels in neutrophils, which were measured until 48 hours after reperfusion. I-123 β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) scintigraphy was performed within a week of reperfusion therapy. In 64% of patients, thallium-201 (TL) scintigraphy was performed 6-8 months after STEMI onset.

Using BMIPP and TL, in the PA (-) subgroups, the iPoC (+) group had a significantly greater myocardial salvage ratio than the iPoC (-) group. iPoC was identified as an independent predictor of the myocardial salvage ratio. The HSP72 increase ratio was significantly elevated in the iPoC (+) PA (-) group. Importantly, the myocardial salvage effect in patients without PA was significantly correlated with the HSP72 increase ratio, which was greater in patients with iPoC.

These results suggest the potential impact of iPoC via HSP72 induction on myocardial salvage; however, the effects may be limited to patients with STEMI without PA.

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来源期刊
International heart journal
International heart journal 医学-心血管系统
CiteScore
2.50
自引率
6.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Authors of research articles should disclose at the time of submission any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Such information will be held in confidence while the paper is under review and will not influence the editorial decision, but if the article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be communicated to the reader.
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