{"title":"一种新型水溶性喹喔啉并[2,3-a]吩嗪基有机近红外光热剂在癌症光疗中的应用","authors":"Siqi Liu, Xu Zhao, Hongying Ding, Liuyi Yang, Meng Zhao, Gaolei Xi, Tao Jia","doi":"10.1007/s12039-024-02262-w","DOIUrl":null,"url":null,"abstract":"<div><p>Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties and photostability, along with outstanding outcomes in cancer phototherapy.</p><h3>Graphical abstract</h3><p>A novel donor-acceptor (D-A)-type organic photothermal material 5,18-dibutyl-5,18- dihydro-diquinoxaline[2,3-a:2',3'-c]-phenazine (DDHT) was encapsulated with Pluronic<sup>®</sup> 127 (F127) material to form NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties with photothermal conversion efficiency of 51.55% under 655 nm NIR laser irradiation, along with outstanding outcomes in cancer therapy.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel water-soluble quinoxalino[2,3-a] phenazine-based organic NIR photothermal agent for cancer phototherapy application\",\"authors\":\"Siqi Liu, Xu Zhao, Hongying Ding, Liuyi Yang, Meng Zhao, Gaolei Xi, Tao Jia\",\"doi\":\"10.1007/s12039-024-02262-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties and photostability, along with outstanding outcomes in cancer phototherapy.</p><h3>Graphical abstract</h3><p>A novel donor-acceptor (D-A)-type organic photothermal material 5,18-dibutyl-5,18- dihydro-diquinoxaline[2,3-a:2',3'-c]-phenazine (DDHT) was encapsulated with Pluronic<sup>®</sup> 127 (F127) material to form NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties with photothermal conversion efficiency of 51.55% under 655 nm NIR laser irradiation, along with outstanding outcomes in cancer therapy.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":616,\"journal\":{\"name\":\"Journal of Chemical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12039-024-02262-w\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s12039-024-02262-w","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A novel water-soluble quinoxalino[2,3-a] phenazine-based organic NIR photothermal agent for cancer phototherapy application
Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties and photostability, along with outstanding outcomes in cancer phototherapy.
Graphical abstract
A novel donor-acceptor (D-A)-type organic photothermal material 5,18-dibutyl-5,18- dihydro-diquinoxaline[2,3-a:2',3'-c]-phenazine (DDHT) was encapsulated with Pluronic® 127 (F127) material to form NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties with photothermal conversion efficiency of 51.55% under 655 nm NIR laser irradiation, along with outstanding outcomes in cancer therapy.
期刊介绍：
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.
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