开发用于肝脏再生的 MKK4 抑制剂

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-05-15 DOI:10.1038/s41575-024-00940-1

Jordan Hindson

引用次数: 0

摘要

激酶 MKK4 是肝细胞再生的调节因子。发表在《细胞》（Cell）杂志上的一项新研究报告了MKK4小分子抑制剂的开发情况。HRX215 增加了小鼠和猪模型肝切除术后的肝再生能力，并增加了部分肝切除术后纤维化小鼠肝脏中肝细胞的增殖。此外，HRX215 治疗还能防止猪肝切除术后肝功能衰竭（85% 的致命性肝切除术模型），并使猪存活下来。接下来，HRX215 的 I 期试验（EudraCT 2021-000193-28；n = 48 名健康志愿者）显示了良好的安全性和药代动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Development of MKK4 inhibitors for liver regeneration

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.