Hanan K. Mosbah, Ahmed B. M Ibrahim, Amna S. A. Zidan, Aref A. M. Aly, Saber H. Saber
{"title":"含有氨基甲酸配体的 La(III)、Ce(III)、Pr(III) 和 Eu(III) 复合物：制备、光谱和热分析及其在 MDA-MB-231 乳腺癌细胞中的细胞毒性评估","authors":"Hanan K. Mosbah, Ahmed B. M Ibrahim, Amna S. A. Zidan, Aref A. M. Aly, Saber H. Saber","doi":"10.1007/s13738-024-03033-7","DOIUrl":null,"url":null,"abstract":"<div><p>Six lanthanide complexes with substituted fenamic acid ligands {[La(L<sup>1</sup>)<sub>3</sub>].2H<sub>2</sub>O (C1), [La(L<sup>2</sup>)<sub>3</sub>].2H<sub>2</sub>O (C2), [Ce(L<sup>1</sup>)<sub>3</sub>] (C3), [Ce(L<sup>2</sup>)<sub>3</sub>].2H<sub>2</sub>O (C4), [Pr(L<sup>1</sup>)<sub>3</sub>].3H<sub>2</sub>O (C5) and [Eu(L<sup>2</sup>)<sub>3</sub>] (C6); HL<sup>1</sup> = 2-(4-chlorophenylamino)benzoic acid and HL<sup><b>2 </b></sup>= 2-(4-methoxyphenylamino)benzoic acid} were isolated and characterized by elemental CHN microanalyses, DMF solution electrical conductivities and spectral (FTIR and UV–Visible) data. These analyses assigned the monoanionic character of the ligands and their bidentate chelation mode through the carboxylate group oxygen atoms. In addition, the complexes dissolve in dichloromethane, dimethylformamide and dimethyl sulfoxide, and are nonelectrolytes. Thermo-analytical techniques (TG/DTA) analyzed the complexes in the air and revealed that all water contained in them is lattice-based (uncoordinated), while complexes C3 and C6 are anhydrous. Moreover, all complexes, during heating up to 700 °C, decomposed to the respective oxides (Ln<sub>2</sub>O<sub>3</sub>). The complexes were tested for potential activity against human MDA-MB-231 breast cancer cells and the results uncovered low cytotoxic effect with high IC<sub>50</sub> doses, comparing to paclitaxel, on these cells.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"La(III), Ce(III), Pr(III) and Eu(III) complexes with fenamic acid based ligands: preparation, spectral and thermal analysis and evaluation of their cytotoxicity in MDA-MB-231 breast cancer cells\",\"authors\":\"Hanan K. Mosbah, Ahmed B. M Ibrahim, Amna S. A. Zidan, Aref A. M. Aly, Saber H. Saber\",\"doi\":\"10.1007/s13738-024-03033-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Six lanthanide complexes with substituted fenamic acid ligands {[La(L<sup>1</sup>)<sub>3</sub>].2H<sub>2</sub>O (C1), [La(L<sup>2</sup>)<sub>3</sub>].2H<sub>2</sub>O (C2), [Ce(L<sup>1</sup>)<sub>3</sub>] (C3), [Ce(L<sup>2</sup>)<sub>3</sub>].2H<sub>2</sub>O (C4), [Pr(L<sup>1</sup>)<sub>3</sub>].3H<sub>2</sub>O (C5) and [Eu(L<sup>2</sup>)<sub>3</sub>] (C6); HL<sup>1</sup> = 2-(4-chlorophenylamino)benzoic acid and HL<sup><b>2 </b></sup>= 2-(4-methoxyphenylamino)benzoic acid} were isolated and characterized by elemental CHN microanalyses, DMF solution electrical conductivities and spectral (FTIR and UV–Visible) data. These analyses assigned the monoanionic character of the ligands and their bidentate chelation mode through the carboxylate group oxygen atoms. In addition, the complexes dissolve in dichloromethane, dimethylformamide and dimethyl sulfoxide, and are nonelectrolytes. Thermo-analytical techniques (TG/DTA) analyzed the complexes in the air and revealed that all water contained in them is lattice-based (uncoordinated), while complexes C3 and C6 are anhydrous. Moreover, all complexes, during heating up to 700 °C, decomposed to the respective oxides (Ln<sub>2</sub>O<sub>3</sub>). The complexes were tested for potential activity against human MDA-MB-231 breast cancer cells and the results uncovered low cytotoxic effect with high IC<sub>50</sub> doses, comparing to paclitaxel, on these cells.</p></div>\",\"PeriodicalId\":676,\"journal\":{\"name\":\"Journal of the Iranian Chemical Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Iranian Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13738-024-03033-7\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Iranian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13738-024-03033-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
La(III), Ce(III), Pr(III) and Eu(III) complexes with fenamic acid based ligands: preparation, spectral and thermal analysis and evaluation of their cytotoxicity in MDA-MB-231 breast cancer cells
Six lanthanide complexes with substituted fenamic acid ligands {[La(L1)3].2H2O (C1), [La(L2)3].2H2O (C2), [Ce(L1)3] (C3), [Ce(L2)3].2H2O (C4), [Pr(L1)3].3H2O (C5) and [Eu(L2)3] (C6); HL1 = 2-(4-chlorophenylamino)benzoic acid and HL2 = 2-(4-methoxyphenylamino)benzoic acid} were isolated and characterized by elemental CHN microanalyses, DMF solution electrical conductivities and spectral (FTIR and UV–Visible) data. These analyses assigned the monoanionic character of the ligands and their bidentate chelation mode through the carboxylate group oxygen atoms. In addition, the complexes dissolve in dichloromethane, dimethylformamide and dimethyl sulfoxide, and are nonelectrolytes. Thermo-analytical techniques (TG/DTA) analyzed the complexes in the air and revealed that all water contained in them is lattice-based (uncoordinated), while complexes C3 and C6 are anhydrous. Moreover, all complexes, during heating up to 700 °C, decomposed to the respective oxides (Ln2O3). The complexes were tested for potential activity against human MDA-MB-231 breast cancer cells and the results uncovered low cytotoxic effect with high IC50 doses, comparing to paclitaxel, on these cells.
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JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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