通过 Knoevenagel-phospha-Michael 方案改进的微波辅助新型吡唑膦酸盐的快速一锅合成方法

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-05-08 DOI:10.1002/jhet.4825

Sara Mahdjoub, Chamseddine Derabli, Muhammet Yildirim, Raouf Boulcina, Abdelmadjid Debache

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引用次数: 0

摘要

本研究建立了一种采用多组分多米诺 Knoevenagel/phospha-Michael 反应的高效微波辅助方法。这种方法通过将芳基醛与吡唑酮和三烷基膦结合，利用哌啶作为勃朗斯特催化剂，以良好的收率合成了一组新型吡唑基膦酸盐衍生物。所有吡唑基膦酸盐都通过红外光谱、1H-NMR、13C-NMR、HRMS 分析和物理方法进行了表征。该方法具有环保、产品收率高、反应时间短等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An improved microwave-assisted facile one-pot synthesis of novel pyrazolylphosphonates via Knoevenagel-phospha-Michael protocol

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An improved microwave-assisted facile one-pot synthesis of novel pyrazolylphosphonates via Knoevenagel-phospha-Michael protocol

In this study, a highly effective microwave-assisted method employing a multicomponent domino Knoevenagel/phospha-Michael reaction has been established. This approach facilitates the synthesis of a novel set of pyrazolylphosphonate derivatives in good yields by combining aryl aldehydes with pyrazolones and trialkylphosphites, utilizing piperidine as a Bronsted base catalyst. All pyrazolylphosphonates have been characterized by means of IR, ¹H-NMR, ¹³C-NMR, and HRMS analyses and physical methods. This protocol can be characterized by its eco-friendly nature, exceptional efficiency in terms of product yields, and short reaction times.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.