研究戒烟意愿和 HDAC9 基因常见下游变异对大动脉粥样硬化性脑梗死的影响
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摘要
摘要研究海南省汉族人群戒烟意愿及HDAC9基因单核苷酸多态性与LAA-S的相关性：方法：进行病例对照研究。方法：采用 SNPscan 基因分型技术对海南汉族人群中的 248 例 LAA-S 患者和 237 例对照进行了 HDAC9 基因的 6 个单核苷酸多态性（SNPS）基因分型。对病例组和对照组的 SNP 位点（rs10227612、rs12669496、rs1548577、rs2074633、rs2526626 和 rs2717344）进行了基因分型，并比较了病例组和对照组的基因型和等位基因频率。结果：（1）病例组 rs10227612 的 GT 基因型、rs2717344 的 GG 基因型和 rs1548577 的 GA 基因型明显高于对照组，差异有统计学意义。(2）病例组和对照组的吸烟分布有显著差异（P <0.05），病例组和对照组随访 3 年和 7 年后的戒烟情况有显著差异（P <0.05）。结论：（1）HDAC9基因的rs10227612、rs1548577、rs2074633、rs2717344可能与海南汉族人群大动脉粥样硬化性脑梗死显著相关，而rs12669496和rs2526626可能无关。(2）根据病例组和对照组吸烟情况统计，吸烟与大动脉粥样硬化性脑梗死有关，戒烟意愿是影响戒烟成功的重要因素：HDAC9 SNP LAA-S 海南籍 戒烟意愿本文章由计算机程序翻译，如有差异，请以英文原文为准。
To Investigate the Influence of Smoking Cessation Intention and Common Downstream Variants of HDAC9 Gene on Large Artery Atherosclerotic Cerebral Infarction
Objective: To investigate the association of smoking cessation intention and single nucleotide polymorphism of HDAC9 gene with LAA-S in Han people in Hainan province.
Methods: A case-control study was conducted. Six single nucleotide polymorphisms (SNPS) of HDAC9 gene were genotyped by SNPscan genotyping technique in 248 patients with LAA-S and 237 controls in Hainan Han population. SNP loci (rs10227612, rs12669496, rs1548577, rs2074633, rs2526626, and rs2717344) were genotyped, and the genotype and allele frequencies were compared between the case and control group. At the same time, the distribution of smoking between the case and control group was compared, and the 3-year and 7-year follow-up smoking cessation between the case and control group was compared, so as to find out the effects of smoking cessation intention and HDAC9 SNP on LAA-S.
Results: (1) The GT genotype at rs10227612, GG genotype at rs2717344, and GA genotype at rs1548577 in the case group were significantly higher than those in the control group, and the differences were statistically significant. (2) There were significant differences in the distribution of smoking between the case and control group (P < 0.05), and there were significant differences in the smoking cessation after 3 years and 7 years of follow-up between the case and control group (P < 0.05). The intention to quit smoking was positively correlated with the incidence of LAA-S.
Conclusion: (1) The rs10227612, rs1548577, rs2074633, rs2717344 of HDAC9 gene may be significantly related to atherosclerotic cerebral infarction of great arteries in Hainan Han population, while rs12669496 and rs2526626 may not be related. (2) According to the statistics of smoking in the case and control group, smoking was related to large artery atherosclerotic cerebral infarction, and the intention to quit smoking was a very important factor affecting the success of smoking cessation.
Keywords: HDAC9, SNP, LAA-S, Hainan nationality, willingness to quit smoking
Methods: A case-control study was conducted. Six single nucleotide polymorphisms (SNPS) of HDAC9 gene were genotyped by SNPscan genotyping technique in 248 patients with LAA-S and 237 controls in Hainan Han population. SNP loci (rs10227612, rs12669496, rs1548577, rs2074633, rs2526626, and rs2717344) were genotyped, and the genotype and allele frequencies were compared between the case and control group. At the same time, the distribution of smoking between the case and control group was compared, and the 3-year and 7-year follow-up smoking cessation between the case and control group was compared, so as to find out the effects of smoking cessation intention and HDAC9 SNP on LAA-S.
Results: (1) The GT genotype at rs10227612, GG genotype at rs2717344, and GA genotype at rs1548577 in the case group were significantly higher than those in the control group, and the differences were statistically significant. (2) There were significant differences in the distribution of smoking between the case and control group (P < 0.05), and there were significant differences in the smoking cessation after 3 years and 7 years of follow-up between the case and control group (P < 0.05). The intention to quit smoking was positively correlated with the incidence of LAA-S.
Conclusion: (1) The rs10227612, rs1548577, rs2074633, rs2717344 of HDAC9 gene may be significantly related to atherosclerotic cerebral infarction of great arteries in Hainan Han population, while rs12669496 and rs2526626 may not be related. (2) According to the statistics of smoking in the case and control group, smoking was related to large artery atherosclerotic cerebral infarction, and the intention to quit smoking was a very important factor affecting the success of smoking cessation.
Keywords: HDAC9, SNP, LAA-S, Hainan nationality, willingness to quit smoking
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