利用计算方法预测间充质干细胞中与年龄相关的微RNA特征

Mohammad Salehi, Majid Darroudi, Maryam Musavi, Amir Abaas Momtazi-Borojeni
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引用次数: 0

摘要

背景:衰老是一种随着时间推移而发生并导致生物体衰亡的现象。在衰老过程中,一些与年龄相关的疾病可能会发生,包括心血管疾病、癌症以及神经、精神和身体疾病。遗传和表观遗传因子,如作为基因转录后调控因子之一的 microRNA,在衰老过程中发挥着重要作用。间充质干细胞的自我更新和分化能力使其成为再生医学的良好候选者:本研究旨在利用生物信息学分析评估人间充质干细胞中与衰老相关的 miRNA:本研究使用基因表达总库(GEO)数据库调查衰老相关基因组概况。然后,选择表达下调的基因进行进一步的生物信息学分析,假设这些基因的表达减少与衰老过程的加剧有关。考虑到 miRNA 可干扰基因表达,我们使用生物信息学软件识别了与这些基因互补的 miRNA:结果:通过生物信息学分析,我们预测了hsa-miR-590-3p、hsa-miR-10b-3p、hsamiR- 548家族、hsa-miR-144-3p和hsa-miR-30b-5p,它们参与了细胞衰老和人类间充质干细胞的衰老。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of Age-Related MicroRNA Signature in Mesenchymal Stem Cells by using Computational Methods.

Background: Aging is a phenomenon which occurs over time and leads to the decay of living organisms. During the progression of aging, some age-associated diseases including cardiovascular disease, cancers, and neurological, mental, and physical disorders could develop. Genetic and epigenetic factors like microRNAs, as one of the post-transcriptional regulators of genes, play important roles in senescence. The self-renewal and differentiation capacity of mesenchymal stem cells makes them good candidates for regenerative medicine.

Objective: The objective of this study is to evaluate senescence-related miRNAs in human MSCs using bioinformatics analysis.

Methods: In this study, the Gene Expression Omnibus (GEO) database was used to investigate the senescence-related genome profile. Then, down-regulated genes were selected for further bioinformatics analysis with the assumption that their decreased expression is associated with an increased aging process. Considering that miRNAs can interfere in gene expression, miRNAs complementary to these genes were identified using bioinformatics software.

Results: Through bioinformatics analysis, we predicted hsa-miR-590-3p, hsa-miR-10b-3p, hsamiR- 548 family, hsa-miR-144-3p, and hsa-miR-30b-5p which involve in cellular senescence and the aging of human MSCs.

Conclusion: miRNA mimics or anti-miRNA agents have the potential to be used as anti-aging tools for MSCs.

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