复发性胰腺尖细胞癌老年患者在接受全身化疗、化放疗和维持治疗后的长期生存率。

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinical Journal of Gastroenterology Pub Date : 2024-08-01 Epub Date: 2024-05-14 DOI:10.1007/s12328-024-01981-4

Makiko Urabe, Kenji Ikezawa, Kazuhiro Kozumi, Yugo Kai, Ryoji Takada, Kaori Mukai, Tasuku Nakabori, Hiroyuki Uehara, Hirofumi Akita, Kazuyoshi Ohkawa

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引用次数: 0

摘要

胰腺尖细胞癌（PACC）是一种罕见的癌症，目前尚无特效疗法。PACC的治疗和化疗是根据胰腺导管腺癌（PDAC）来选择的。在此，我们描述了一名老年患者的复发性 PACC 病例。该患者接受了全身化疗、化放疗和基于病理种系 BRCA2 变异的维持治疗，获得了长期生存。与 PDAC 患者相比，PACC 患者更常检测到致病性 BRCA 变异。BRCA 变异对治疗选择和预后有重大影响；因此，建议在治疗 PACC 时尽早进行基因组分析。

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Long-term survival after systemic chemotherapy, chemoradiotherapy, and maintenance therapy for an older adult patient with recurrent pancreatic acinar cell carcinoma.

Pancreatic acinar cell carcinoma (PACC) is a rare cancer with no specific treatment. The treatment and chemotherapy for PACC are selected according to pancreatic ductal adenocarcinoma (PDAC). Herein, we describe a recurrent PACC case of an older adult patient. The patient was treated with systemic chemotherapy, chemoradiotherapy, and maintenance therapy based on the pathologic germline BRCA2 variant, resulting in long-term survival. The pathogenic BRCA variant is detected more frequently in patients with PACC than in those with PDAC. The BRCA variant significantly impacts treatment selection and prognosis; therefore, early genomic analysis is recommended when treating PACC.

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来源期刊

Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

182

期刊介绍： The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.