用[68Ga]Ga-pentixafor对瓦尔登斯特伦巨球蛋白血症和烟雾病患者进行趋化因子受体4靶向PET/CT检查,显示出不同的髓外疾病。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear Medicine Communications Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1097/MNM.0000000000001862
Qingqing Pan, Xinxin Cao, Jian Li, Fang Li, Yaping Luo
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引用次数: 0

摘要

导言:区分瓦尔登斯特伦巨球蛋白血症和烟雾型瓦尔登斯特伦巨球蛋白血症(sWM)非常重要,因为只有瓦尔登斯特伦巨球蛋白血症患者才需要治疗,但这种区分在临床上可能很复杂。本研究旨在探讨[68Ga]Ga-pentixafor PET/CT在sWM和Waldenström巨球蛋白血症患者中是否显示出不同的特征,从而有助于区分Waldenström巨球蛋白血症和sWM:分析了37名新确诊的瓦尔登斯特伦巨球蛋白血症患者和11名sWM患者[男性35名,女性13名;64.3 ± 10.7(范围29-87)岁]。骨髓疾病、淋巴结和其他髓外疾病在[68Ga]Ga-pentixafor上的SUVmax明显高于2-[18F]FDG PET/CT上的SUVmax(P与 2-[18F]FDG PET/CT 相比,[68Ga]Ga-pentixafor PET/CT 对瓦尔登斯特伦巨球蛋白血症的诊断效果更好。Waldenström 巨球蛋白血症患者的[68Ga]Ga-pentixafor PET/CT显示的髓外疾病比sWM患者更广泛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different extramedullary disease shown in chemokine receptor 4 targeted PET/CT with [ 68 Ga]Ga-pentixafor in patients with Waldenström macroglobulinemia and smoldering disease.

Introduction: It is important to distinguish Waldenström macroglobulinemia from smoldering Waldenström macroglobulinemia (sWM), because only patients with Waldenström macroglobulinemia require treatment, however the distinction can be clinically complex. The aim of this study is to investigate whether [ 68 Ga]Ga-pentixafor PET/CT shows different characteristics in sWM and Waldenström macroglobulinemia patients and therefore can help to differentiate Waldenström macroglobulinemia and sWM.

Results: Thirty-seven patients with newly diagnosed Waldenström macroglobulinemia and 11 sWM patients were analyzed [35 men and 13 women; 64.3 ± 10.7 (range, 29-87) years old]. The SUV max of bone marrow disease, lymph nodes, and other extramedullary diseases on [ 68 Ga]Ga-pentixafor were significantly higher than those on 2-[ 18 F]FDG PET/CT ( P  < 0.05). On [ 68 Ga]Ga-pentixafor PET/CT, patients with Waldenström macroglobulinemia had more lymph node regions involved, significantly higher incidence of involvement in more than three lymph node regions, larger nodal disease, and higher incidence of other extramedullary disease when compared with sWM patients ( P  < 0.05). Waldenström macroglobulinemia patients showed significantly higher total lesions uptake, total lesion volume, and SUV max of extramedullary disease than sWM patients did ( P  < 0.05). None of the visual or semiquantitative indexes in 2-[ 18 F]FDG PET/CT showed significant difference between Waldenström macroglobulinemia and sWM patients.

Conclusion: [ 68 Ga]Ga-pentixafor PET/CT had better diagnostic performance than 2-[ 18 F]FDG PET/CT in Waldenström macroglobulinemia. Patients with Waldenström macroglobulinemia presented with more extensive extramedullary disease shown in [ 68 Ga]Ga-pentixafor PET/CT than sWM patients did.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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