肠道微生物组与心血管疾病之间的多组学联系

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-05-14 DOI:10.1038/s41575-024-00941-0

Jordan Hindson

引用次数: 0

摘要

弗雷明汉心脏研究是一项正在进行的观察性队列研究，旨在确定心血管疾病的风险因素。泽维尔及其同事利用研究参与者的数据来研究肠道微生物组与心血管疾病之间的联系。他们生成了 1429 名研究参与者的粪便元基因组和代谢组数据。他们特别发现，奥希氏菌与粪便和血浆胆固醇的降低有关。体外实验发现，从人类肠道中分离出的奥希氏杆菌编码保守的胆固醇代谢酶，加深了我们对肠道微生物组及其代谢物如何影响心血管健康的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.