药用植物的抗菌活性及其在伤口愈合中的作用

IF 3.4 Q2 PHARMACOLOGY & PHARMACY
Zeinab Breijyeh, Rafik Karaman
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引用次数: 0

摘要

背景研究以植物为基础的药物(或称植物药)涉及广泛的生物活性。由于次生代谢物的存在,草药在历史上一直被用于治疗急性和慢性疾病。在过去的一个多世纪里,人们从植物中提取了大量具有药用潜力的新型化合物。摘要正文本综述讨论了草药作为抗菌剂的作用及其在伤口护理和伤口管理中的应用,以及草药植物次生代谢物在抗击细菌感染中的关键作用。一些药用植物,如圣约翰草(SJW)(贯叶连翘)、迷迭香(Rosmarinus officinalis)、生姜(Zingiber officinale)和龙脑仙人掌(Opuntia ficusindica (L.))也具有广泛的生物活性,如果与抗生素结合使用,可产生协同效应。此外,天然生物聚合物在处理伤口以及皮肤的生理过程(止血、炎症、增殖和重塑)中发挥着重要作用。方法通过使用电子数据库 PubMed、CrossREF 和 Google Scholar,对使用植物药治疗感染的相关论文进行了叙述性综述。要了解药用植物的生物活性成分、它们的医疗功效以及它们在增强药物作用方面的协同或相加效应,还需要进行大量新的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial activity of medicinal plants and their role in wound healing

Background

The study of plant-based medications, or phytomedicine, involves a wide spectrum of biological activities. Due to the existence of secondary metabolites, herbal medicine has been used and practiced throughout history for the treatment of both acute and chronic conditions. Over the past century or so, numerous novel compounds with medicinal potential have been derived from plants. In the age of growing super infections and the emergence of resistant strains, natural medicines are inspiring optimism.

Main body of the abstract

The review discusses the role of herbal medicine as antibacterial agents and their use in wound care and management of wounds and the critical role of secondary metabolites of herbal plants in fighting bacterial infections. Some medicinal plants such as St. John’s wort (SJW) (Hypericum perforatum), Rosemary (Rosmarinus officinalis), Ginger (Zingiber officinale), and nopal cactus (Opuntia ficusindica (L.)) also possess wide range of biological activities and can give a synergistic effect if combined with antibiotics. In addition, natural biopolymers play an important role in the management of wounds as well as the physiological processes of the skin (hemostasis, inflammation, proliferation, and remodelling).

Method

A narrative review of papers relevant to the use of phytomedicine in treating infections was conducted by using electronic databases PubMed, CrossREF, and Google Scholar.

Short conclusion

Phytomedicine is one of the top options for the treatment of chronic illnesses for millions of people around the world. To learn about the bioactive components of medicinal plants, their medical benefits, and their synergistic or additive effects to enhance the action of medications, substantial new studies are still needed.

Graphical abstract

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来源期刊
自引率
0.00%
发文量
44
审稿时长
23 weeks
期刊介绍: Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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