地中海蜱(Hyalomma lusitanicum)对红肉过敏的表位 Alpha-Gal。

IF 1.6 3区 农林科学 Q2 ENTOMOLOGY
Ángela Valcárcel, Andrea Briones Montero, Marta Rodero, Juan González-Fernández, A. Sonia Olmeda, Félix Valcárcel, Carmen Cuéllar
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引用次数: 0

摘要

α-Gal/α-Gal是一种由非灵长类哺乳动物产生的寡糖。人类产生了一种由抗α-gal抗体介导的免疫反应,这种抗体可引发过敏反应,导致过敏性休克。近年来,世界各地都出现了对哺乳动物肉类产生迟发性过敏反应的病例。在西班牙,这些病例与分布在该国北部的 Ixodes ricinus L.(Ixodida:Ixodidae)物种有关。在这项工作中,我们研究了从Hyalomma lusitanicum Koch(Ixodida:Ixodidae)的唾液腺和消化道样本中提取的水溶性α-Gal。在两种样本中都发现了大于 250 kDa 的反应蛋白,从而证实了该表位的存在。唾液腺中检测到的 α-Gal 浓度最高。性别和饮食都不影响α-Gal的浓度,这似乎表明α-Gal是由内源性产生的,并有可能在蜱进食时接种到宿主体内。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum

Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum

Alpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.

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来源期刊
Medical and Veterinary Entomology
Medical and Veterinary Entomology 农林科学-昆虫学
CiteScore
3.70
自引率
5.30%
发文量
65
审稿时长
12-24 weeks
期刊介绍: Medical and Veterinary Entomology is the leading periodical in its field. The Journal covers the biology and control of insects, ticks, mites and other arthropods of medical and veterinary importance. The main strengths of the Journal lie in the fields of: -epidemiology and transmission of vector-borne pathogens changes in vector distribution that have impact on the pathogen transmission- arthropod behaviour and ecology- novel, field evaluated, approaches to biological and chemical control methods- host arthropod interactions. Please note that we do not consider submissions in forensic entomology.
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