最新技术：针对胃肠道癌症的微卫星不稳定性。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-05-10 DOI:10.1016/j.critrevonc.2024.104387

Justin Mencel, Anneke Alves, Vasileios Angelis, Marco Gerlinger, Naureen Starling

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引用次数: 0

摘要

DNA错配修复（MMR）缺陷和相关的微卫星不稳定性（MSI）表型近年来已成为一个备受关注的话题，因为免疫检查点抑制剂（ICI）对晚期肿瘤的疗效已得到证实。评估胃肠道（GI）癌症患者的 MSI 不仅有助于排除林奇综合征，还能预测 ICI 的治疗效果。在回顾相关文献后，本综述文章旨在概述消化道、肝胆系统和胰腺中 MSI 和错配修复缺陷（dMMR）的临床病理范围，并讨论该疾病的治疗考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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State of the art: Targeting microsatellite instability in gastrointestinal cancers

DNA mismatch repair (MMR) deficiency and the associated microsatellite instability (MSI) phenotype has become a subject of enormous interest in recent years due to the demonstrated efficacy of immune checkpoint inhibitors (ICI) in advanced tumours. Assessing MSI in patients with gastrointestinal tract (GI) cancers is useful to exclude Lynch syndrome, but also to predict benefit for ICI. Following review of the relevant literature, this review article aims to outline the clinicopathologic spectrum of MSI and mismatch repair deficiency (dMMR) in the GI tract, hepatobiliary system and pancreas and discuss the therapeutic consideration in this disease.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.