视网膜移植免疫学及进展。

IF 5.9 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Reports Pub Date : 2024-06-11 Epub Date: 2024-05-09 DOI:10.1016/j.stemcr.2024.04.007

Victor L Perez, Hazem M Mousa, Kiyoharu J Miyagishima, Amberlynn A Reed, An-Jey A Su, Thomas N Greenwell, Kia M Washington

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引用次数: 0

摘要

将干细胞移植到眼部治疗眼部疾病，尤其是视网膜疾病，仍存在一些差距和障碍。虽然眼睛历来被认为具有免疫特权，但最近的观点认为，免疫系统既是眼部干细胞移植的障碍，也是机会。最近，利用支架或隐形的方法已被考虑用于免疫抑制以外的其他组织。本视角论文概述了移植方法，并提出了在眼部干细胞移植中克服免疫系统障碍的机会。

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Retinal transplant immunology and advancements.

Several gaps and barriers remain for transplanting stem cells into the eye to treat ocular disease, especially diseases of the retina. While the eye has historically been considered immune privileged, recent thinking has identified the immune system as both a barrier and an opportunity for eye stem cell transplantation. Recent approaches leveraging scaffolds or cloaking have been considered in other tissues beyond immune suppression. This perspective paper outlines approaches for transplantation and proposes opportunities to overcome barriers of the immune system in stem cell transplantation in the eye.

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来源期刊

Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

10.50

自引率

1.70%

发文量

200

审稿时长

28 weeks

期刊介绍： Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.