{"title":"甲状腺乳头状癌中 18F- 氟脱氧葡萄糖摄取与代谢相关分子表达的关系","authors":"Tomomi Yoshikawa, Kazuhira Endo, Makiko Moriyama-Kita, Takayoshi Ueno, Yosuke Nakanishi, Hirotomo Dochi, Daisuke Uno, Satoru Kondo, Tomokazu Yoshizaki","doi":"10.1016/j.anl.2024.04.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p><sup>18</sup>F-fluorodeoxyglucose positron emission tomography-computed tomography (<sup>18</sup>F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of <sup>18</sup>F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of <sup>18</sup>F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between <sup>18</sup>F-FDG uptake and tumor metabolism- associated factors.</p></div><div><h3>Methods</h3><p>This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer.</p></div><div><h3>Results</h3><p>GLS1 expression was found to be moderately correlated with SUVmax (<em>p</em> < 0.001, <em>r</em> = 0.51), whereas HK2 and VEGF expression were weakly correlated (<em>p</em> = 0.011, <em>r</em> = 0.28, <em>p</em> = 0.008, <em>r</em> = 0.29, respectively) and GLUT1 did not correlate with SUVmax (<em>p</em> = 0.62, <em>r</em> = 0.06).</p></div><div><h3>Conclusion</h3><p>Our findings suggest <sup>18</sup>F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 4","pages":"Pages 696-702"},"PeriodicalIF":1.6000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of 18F- fluorodeoxyglucose uptake with the expression of metabolism-related molecules in papillary thyroid cancer\",\"authors\":\"Tomomi Yoshikawa, Kazuhira Endo, Makiko Moriyama-Kita, Takayoshi Ueno, Yosuke Nakanishi, Hirotomo Dochi, Daisuke Uno, Satoru Kondo, Tomokazu Yoshizaki\",\"doi\":\"10.1016/j.anl.2024.04.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p><sup>18</sup>F-fluorodeoxyglucose positron emission tomography-computed tomography (<sup>18</sup>F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of <sup>18</sup>F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of <sup>18</sup>F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between <sup>18</sup>F-FDG uptake and tumor metabolism- associated factors.</p></div><div><h3>Methods</h3><p>This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer.</p></div><div><h3>Results</h3><p>GLS1 expression was found to be moderately correlated with SUVmax (<em>p</em> < 0.001, <em>r</em> = 0.51), whereas HK2 and VEGF expression were weakly correlated (<em>p</em> = 0.011, <em>r</em> = 0.28, <em>p</em> = 0.008, <em>r</em> = 0.29, respectively) and GLUT1 did not correlate with SUVmax (<em>p</em> = 0.62, <em>r</em> = 0.06).</p></div><div><h3>Conclusion</h3><p>Our findings suggest <sup>18</sup>F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.</p></div>\",\"PeriodicalId\":55627,\"journal\":{\"name\":\"Auris Nasus Larynx\",\"volume\":\"51 4\",\"pages\":\"Pages 696-702\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Auris Nasus Larynx\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0385814624000580\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Auris Nasus Larynx","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0385814624000580","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Association of 18F- fluorodeoxyglucose uptake with the expression of metabolism-related molecules in papillary thyroid cancer
Objectives
18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of 18F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of 18F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between 18F-FDG uptake and tumor metabolism- associated factors.
Methods
This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer.
Results
GLS1 expression was found to be moderately correlated with SUVmax (p < 0.001, r = 0.51), whereas HK2 and VEGF expression were weakly correlated (p = 0.011, r = 0.28, p = 0.008, r = 0.29, respectively) and GLUT1 did not correlate with SUVmax (p = 0.62, r = 0.06).
Conclusion
Our findings suggest 18F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.
期刊介绍：
The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science.
Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed.
Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.
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