Ruirui Zheng , Raúl Romero-del Rey , Fátima Ruiz-Moreno , Jessica Garcia-Gonzalez , Mar Requena-Mullor , A. Ángela Navarro-Mena , Antonia López-Villén , Raquel Alarcon-Rodriguez
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引用次数: 0
摘要
杀虫剂可保护作物健康，但可能会降低农民体内胆碱酯酶的活性，从而可能导致抑郁症和自杀企图等精神疾病。这项研究在西班牙阿尔梅里亚有 453 名参与者（225 名接触过杀虫剂的农民，228 名非农民），旨在调查农民是否存在抑郁症状和自杀企图、乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）活性的降低及其与接触杀虫剂的关系。采用贝克抑郁量表的西班牙语改编版对抑郁症状进行了评估，并对血液样本进行了乙酰胆碱酯酶和丁酰胆碱酯酶活性分析。与非农民相比，农民患中度/重度抑郁症和企图自杀的风险明显增加（OR = 2.18；p = 0.001），其中使用代森锰锌的风险最高（抑郁症的 OR = 2.76；p = 0.001），使用马拉硫磷的风险最高（OR = 3.50；企图自杀的 p = 0.001）。研究结果表明，接触农药的农民患抑郁症和自杀的风险较高，尤其是接触毒死蜱、代森锰锌和马拉硫磷的农民。
Depressive symptoms and suicide attempts among farmers exposed to pesticides
Pesticides safeguard crop health but may diminish cholinesterase activity in farmers, potentially leading to psychiatric disorders like depression and suicide attempts. This study, with 453 participants (225 pesticide-exposed farmers, 228 non-farmers) in Almería, Spain, aimed to investigate the presence of depressive symptoms and suicide attempts, the decrease acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, and their relationship with pesticide exposure in farmers. Depressive symptoms were evaluated using the Spanish adaptation of the Beck Depression Inventory, and blood samples were analyzed for AChE and BChE activity. Farmers showed significantly increased risk of moderate/severe depression and suicide attempts compared to non-farmers (OR = 2.18; p = 0.001), with highest risks observed among mancozeb users (OR = 2.76; p = 0.001 for depression) and malathion users (OR = 3.50; p = 0.001 for suicide attempts). Findings emphasize elevated depression and suicide risks among pesticide-exposed farmers, particularly associated with chlorpyrifos, mancozeb, and malathion exposure.
期刊介绍：
Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man.
Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals.
In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.
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