利用 Olink 技术发现靶向蛋白质组学的方法和临床生物标记物。

IF 2.1 4区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

PROTEOMICS – Clinical Applications Pub Date : 2024-09-01 Epub Date: 2024-05-10 DOI:10.1002/prca.202300233

Han Wang, Tian Zhao, Jingjing Zeng, Ruijie Zhang, Liyuan Pu, Suying Qian, Shan Xu, Yannan Jiang, Lifang Pan, Xiaoyu Dai, Xu Guo, Liyuan Han

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引用次数: 0

摘要

目的：本文旨在为利用Olink技术确定疾病治疗的生物标志物和潜在治疗靶点的研究设计提供见解：我们讨论了Olink技术在肿瘤、心血管、呼吸和免疫相关疾病中的应用，并概述了Olink技术的优势和局限性：结果：Olink 技术简化了治疗靶点的搜索过程，推动了蛋白质组学研究的发展，揭示了疾病的发病机制，并最终帮助患者进行精准治疗：虽然近年来蛋白质组学技术得到了快速发展，但每种方法都有其自身的缺点，因此在未来的研究中，应选择更多的方法进行联合应用，以相互验证。

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Methods and clinical biomarker discovery for targeted proteomics using Olink technology.

Purpose: This paper is to offer insights for designing research utilizing Olink technology to identify biomarkers and potential therapeutic targets for disease treatment.

Experimental design: We discusses the application of Olink technology in oncology, cardiovascular, respiratory and immune-related diseases, and Outlines the advantages and limitations of Olink technology.

Results: Olink technology simplifies the search for therapeutic targets, advances proteomics research, reveals the pathogenesis of diseases, and ultimately helps patients develop precision treatments.

Conclusions: Although proteomics technology has been rapidly developed in recent years, each method has its own disadvantages, so in the future research, more methods should be selected for combined application to verify each other.

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来源期刊

PROTEOMICS – Clinical Applications 医学-生化研究方法

CiteScore

5.20

自引率

5.00%

发文量

审稿时长

1 months

期刊介绍： PROTEOMICS - Clinical Applications has developed into a key source of information in the field of applying proteomics to the study of human disease and translation to the clinic. With 12 issues per year, the journal will publish papers in all relevant areas including: -basic proteomic research designed to further understand the molecular mechanisms underlying dysfunction in human disease -the results of proteomic studies dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers -the use of proteomics for the discovery of novel drug targets -the application of proteomics in the drug development pipeline -the use of proteomics as a component of clinical trials.