用于靶向给药的定制蛋白质纳米颗粒

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-09 DOI:10.1038/s41594-024-01289-4

引用次数: 0

摘要

靶向生物制剂递送需要对多组分蛋白质纳米材料进行编程，以便在一个统一的框架内实现选择性靶向并对环境变化做出反应。我们设计了一种新型蛋白质纳米粒子平台，用于调节细胞表面靶标特异性、货物包装以及随 pH 值变化的封装货物释放，为生物制剂递送提供了令人兴奋的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Custom protein nanoparticles for targeted drug delivery

查看原文本刊更多论文

Custom protein nanoparticles for targeted drug delivery

Targeted biologics delivery requires programming multicomponent protein nanomaterials to enable selective targeting and response to environment changes in a single unified framework. A novel protein nanoparticle platform has been designed to modulate cell-surface target specificity, cargo packaging, and pH-dependent release of encapsulated cargo, providing exciting possibilities in biologics delivery.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.