性别对 2 型糖尿病患者慢性并发症的影响:一项横断面研究的证据

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM
Kiavash Mokhtarpour, Amirhossein Yadegar, Fatemeh Mohammadi, Seyedeh Nazanin Aghayan, Seyed Arsalan Seyedi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani
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引用次数: 0

摘要

简介:本研究旨在评估和比较男性和女性 2 型糖尿病患者的糖尿病并发症发病率,以及性别与这些并发症的关系:本研究旨在评估和比较2型糖尿病(T2D)男性和女性患者的糖尿病并发症发病率,以及性别与这些并发症的关系:在这项横断面研究中,对 1867 名 2 型糖尿病患者的糖尿病并发症进行了评估,包括冠状动脉疾病(CAD)、视网膜病变、神经病变和糖尿病肾病(DKD)。此外,还评估了这些人的基线特征,包括人体测量、代谢参数以及血脂异常药物和降糖药物的使用情况。采用卡方检验对并发症的性别差异进行了研究。在对研究人群的特征进行调整或未进行调整的情况下,采用多变量逻辑回归法研究性别与终末期糖尿病并发症之间的关系:在研究人群中,62.1%的人至少患有一种并发症,其中33.5%的人患有糖尿病、29.6%的人患有冠状动脉硬化症、22.9%的人患有神经病变、19.1%的人患有视网膜病变。男性患 CAD 和神经病变的比例较高。然而,DKD 和视网膜病变在女性中更为普遍。在对人口统计学因素、人体测量指标、代谢参数以及服用血脂异常药物和降糖药物进行调整后,男性与女性发生任何并发症、CAD和视网膜病变的比值比分别为1.57(95% CI:1.27-2.03)、2.27(95% CI:1.72-2.99)和0.72(95% CI:0.52-0.98):结论:男性糖尿病患者的糖尿病并发症发病率明显更高,这说明需要更好地坚持治疗。糖尿病并发症与男性有关,而视网膜病变则与女性有关。无论男性和女性糖尿病患者的年龄、糖尿病病程、人体测量指标、实验室检查结果和用药情况如何,都应分别密切监测他们是否患有并发症和视网膜病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of Gender on Chronic Complications in Participants With Type 2 Diabetes: Evidence From a Cross-Sectional Study

Impact of Gender on Chronic Complications in Participants With Type 2 Diabetes: Evidence From a Cross-Sectional Study

Introduction

This study aimed to assess and compare the prevalence of diabetes complications between men and women with Type 2 diabetes (T2D), as well as how gender relates to these complications.

Methods

In this cross-sectional study, complications of diabetes, including coronary artery disease (CAD), retinopathy, neuropathy and diabetic kidney disease (DKD), were evaluated in 1867 participants with T2D. Additionally, baseline characteristics of the individuals, including anthropometric measurements, metabolic parameters and the use of dyslipidaemia drugs and antihyperglycaemic agents, were assessed. Gender differences in complications were examined using the chi-squared test. Multivariate logistic regression was employed to investigate the relationship between gender and T2D complications, with and without adjusting for the characteristics of the studied population.

Results

In the studied population, 62.1% had at least one complication, and complications were 33.5% for DKD, 29.6% for CAD, 22.9% for neuropathy and 19.1% for retinopathy. The prevalence of CAD and neuropathy was higher in men. However, DKD and retinopathy were more prevalent among women. Odds ratios of experiencing any complication, CAD and retinopathy in men compared with women were 1.57 (95% CI: 1.27–2.03), 2.27 (95% CI: 1.72–2.99) and 0.72 (95% CI: 0.52–0.98), respectively, after adjusting for demographic factors, anthropometric measures, metabolic parameters and the consumption of dyslipidaemia drugs and antihyperglycaemic agents.

Conclusion

The prevalence of diabetes complications was significantly higher in men with diabetes, highlighting the need for better treatment adherence. CAD was associated with the male gender, whereas retinopathy was associated with the female gender. Men and women with diabetes should be monitored closely for CAD and retinopathy, respectively, regardless of their age, diabetes duration, anthropometric measures, laboratory findings and medications.

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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
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0.00%
发文量
66
审稿时长
6 weeks
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