寻找非洲猪瘟病毒包膜蛋白中的潜在表位

IF 0.6 4区材料科学 Q4 CRYSTALLOGRAPHY

Crystallography Reports Pub Date : 2024-02-05 DOI:10.1134/s1063774523601077

I. A. Kolesnikov, V. I. Timofeev, A. V. Ermakov, A. S. Ivanovsky, Yu. A. Dyakova, Yu. V. Pisarevsky, M. V. Kovalchuk

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引用次数: 0

摘要

摘要建立了非洲猪瘟（ASF）病毒包膜蛋白的空间结构模型，计算了其相对于细胞膜的拓扑结构，预测了该蛋白的B细胞和T细胞表位，并估计了其免疫原性、过敏性和毒性。研究了蛋白质氨基酸的可变性和所发现表位的保守性。研究表明，可以根据所发现的表位开发出一种新的抗 ASF 肽疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

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Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

Abstract

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.

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来源期刊

Crystallography Reports 化学-晶体学

CiteScore

1.10

自引率

28.60%

发文量

审稿时长

4-8 weeks

期刊介绍： Crystallography Reports is a journal that publishes original articles short communications, and reviews on various aspects of crystallography: diffraction and scattering of X-rays, electrons, and neutrons, determination of crystal structure of inorganic and organic substances, including proteins and other biological substances; UV-VIS and IR spectroscopy; growth, imperfect structure and physical properties of crystals; thin films, liquid crystals, nanomaterials, partially disordered systems, and the methods of studies.