{"title":"ZnAl2O4/SiO2 纳米催化剂：一种在安全、绿色和无溶剂条件下与特定产物进行比吉内利反应的新型高效催化剂","authors":"Soodabeh Gharibeh","doi":"10.1007/s13738-024-03020-y","DOIUrl":null,"url":null,"abstract":"<div><p>Lewis acid heterogeneous catalyst, ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> nanocomposite, was determined as a strong catalyst for the green and safe three-component reactions by the one-pot procedure. The effect of factors, such as the amount of catalyst, the molar ratio of reactants, reflux time and temperature on the three-component reactions were investigated. Also, the parameters of green chemistry were studied. These reactions under solvent-free conditions in the presence of ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> dramatically increased the yield of the formation of dihydropyrimidinones derivatives in a very short time. The results showed that ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> under solvent-free conditions greatly accelerate the three-component reactions with the advance of imine pathway and preventing the formation of unwanted side-products. Also, aromatic aldehydes with low electron density had the best outcomes. Lower reaction yield was produced by β-ketoesters with more steric hindrance. Without noticeably altering reaction time or yield, this catalyst employed six times. The technique is environmentally friendly, as shown by its low E-factor of 0.218–0.570 and high atom economy of 90.025–87.237.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ZnAl2O4/SiO2 nanocatalyst: a new efficient catalyst for Biginelli reaction with a specific product under safe, green, and solvent-free conditions\",\"authors\":\"Soodabeh Gharibeh\",\"doi\":\"10.1007/s13738-024-03020-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lewis acid heterogeneous catalyst, ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> nanocomposite, was determined as a strong catalyst for the green and safe three-component reactions by the one-pot procedure. The effect of factors, such as the amount of catalyst, the molar ratio of reactants, reflux time and temperature on the three-component reactions were investigated. Also, the parameters of green chemistry were studied. These reactions under solvent-free conditions in the presence of ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> dramatically increased the yield of the formation of dihydropyrimidinones derivatives in a very short time. The results showed that ZnAl<sub>2</sub>O<sub>4</sub>/SiO<sub>2</sub> under solvent-free conditions greatly accelerate the three-component reactions with the advance of imine pathway and preventing the formation of unwanted side-products. Also, aromatic aldehydes with low electron density had the best outcomes. Lower reaction yield was produced by β-ketoesters with more steric hindrance. Without noticeably altering reaction time or yield, this catalyst employed six times. The technique is environmentally friendly, as shown by its low E-factor of 0.218–0.570 and high atom economy of 90.025–87.237.</p></div>\",\"PeriodicalId\":676,\"journal\":{\"name\":\"Journal of the Iranian Chemical Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Iranian Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13738-024-03020-y\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Iranian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13738-024-03020-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
ZnAl2O4/SiO2 nanocatalyst: a new efficient catalyst for Biginelli reaction with a specific product under safe, green, and solvent-free conditions
Lewis acid heterogeneous catalyst, ZnAl2O4/SiO2 nanocomposite, was determined as a strong catalyst for the green and safe three-component reactions by the one-pot procedure. The effect of factors, such as the amount of catalyst, the molar ratio of reactants, reflux time and temperature on the three-component reactions were investigated. Also, the parameters of green chemistry were studied. These reactions under solvent-free conditions in the presence of ZnAl2O4/SiO2 dramatically increased the yield of the formation of dihydropyrimidinones derivatives in a very short time. The results showed that ZnAl2O4/SiO2 under solvent-free conditions greatly accelerate the three-component reactions with the advance of imine pathway and preventing the formation of unwanted side-products. Also, aromatic aldehydes with low electron density had the best outcomes. Lower reaction yield was produced by β-ketoesters with more steric hindrance. Without noticeably altering reaction time or yield, this catalyst employed six times. The technique is environmentally friendly, as shown by its low E-factor of 0.218–0.570 and high atom economy of 90.025–87.237.
期刊介绍：
JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
