IgA 肾病患者的 IgA+ 类切换 CD27-CD21+ B 细胞分化增强

medRxiv - Nephrology Pub Date : 2024-05-02 DOI:10.1101/2024.04.29.24306572

Anna Popova, Baiba Slisere, Karlis Racenis, Viktorija Kuzema, Roberts Karklins, Mikus Saulite, Janis Seilis, Anna Jana Saulite, Aiga Vasilvolfa, Kristine Vaivode, Dace Pjanova, Juta Kroica, Harijs Cernevskis, Aivars Lejnieks, Aivars Petersons, Kristine Oleinika

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引用次数: 0

摘要

背景 IgA 肾病（IgAN）的特征是产生半乳糖缺乏性 IgA1（Gd-IgA1）抗体。作为致病抗体的来源，B 细胞是 IgAN 发病机制的核心，但 B 细胞活化途径以及 B 细胞分泌失调 IgA 的潜在来源仍不清楚。

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Enhanced differentiation of IgA+ class-switched CD27-CD21+ B cells in patients with IgA nephropathy

Background IgA nephropathy (IgAN) is characterised by the production of galactose-deficient IgA1 (Gd-IgA1) antibodies. As the source of pathogenic antibodies, B cells are central to IgAN pathogenesis, but the B cell activation pathways as well as the potential B cell source of dysregulated IgA-secretion remain unknown.

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medRxiv - Nephrology

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