通过中尺度 TopBP1 凝聚物点亮 ATR/Chk1。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI:10.1016/j.tcb.2024.04.002

Yan Qin, Lei Shi

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引用次数: 0

摘要

生物分子缩聚作为细胞信号传导和各种生物过程中的一种基本机制受到了广泛关注。Egger 等人最近的一项研究对拓扑异构酶 IIβ 结合蛋白 1（TopBP1）缩合物的组成成分提供了有价值的见解，并揭示了在这些缩合物界面上阿达克氏毛细血管扩张症突变和 Rad3 相关（ATR）激活 Chk1 的机制。

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Lighting ATR/Chk1 by mesoscale TopBP1 condensates.

Biomolecular condensation has gained considerable attention as a fundamental mechanism in cell signaling and various biological processes. A recent study by Egger et al. provides valuable insights into the constituents of topoisomerase IIβ binding protein 1 (TopBP1) condensates and sheds light on the mechanism of Chk1 activation by ataxia telangiectasia-mutated and Rad3-related (ATR) at the interface of these condensates.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.