Cristhiane Olivia Ferreira do Amaral, Kamila Rosamilia Kantovitiz, V. C. de Araújo, T. Marega, L. N. Teixeira, E. F. Martinez
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Biofilm development and pathogenicity of <i>Streptococcus mutans</i> may be altered because FXS renders the dental approach and oral hygiene more complex.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>The purpose of this study was to compare the levels of transcripts for VicRK and CovR of <i>S. mutans</i> isolated from FXS patients with the levels of transcripts for VicRK and CovR of standard strain ATCC, using a quantitative polymerase chain reaction (qPCR).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The caries experience index was assessed by the International Caries Detection and Assessment System (ICDAS), Periodontal Condition Index (PCI) and Invasive Dental Treatment Need Index (INI).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The clinical index findings revealed a high rate of caries cavities and bleeding on probing of FXS patients. When VicRK and CovR transcript levels were compared with the reference strain, Fragile X patients were found to have significantly higher values.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The present study demonstrated that FXS patients have more adverse clinical conditions, with increased biofilm accumulation and virulence. When combined with behavioural abnormalities, these patients become even more vulnerable to dental caries.</p>\n </section>\n </div>","PeriodicalId":16163,"journal":{"name":"Journal of Intellectual Disability Research","volume":"68 9","pages":"1026-1035"},"PeriodicalIF":2.1000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of dental and periodontal indices and Streptococcus mutans virulence in fragile X syndrome patients\",\"authors\":\"Cristhiane Olivia Ferreira do Amaral, Kamila Rosamilia Kantovitiz, V. C. de Araújo, T. Marega, L. N. Teixeira, E. F. Martinez\",\"doi\":\"10.1111/jir.13142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Fragile X syndrome (FXS) is the most common cause of hereditary genetic disorder in a single gene characterised by intellectual disability. 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引用次数: 0
摘要
简介脆性 X 综合征(FXS)是最常见的单基因遗传性疾病,以智力障碍为特征。患者可能存在自闭症、多动和焦虑症等行为特征。由于 FXS 使牙科治疗方法和口腔卫生变得更加复杂,突变链球菌的生物膜发育和致病性可能会发生改变:本研究的目的是使用定量聚合酶链反应(qPCR)比较从FXS患者中分离出的变异链球菌的VicRK和CovR转录本水平与标准菌株ATCC的VicRK和CovR转录本水平:方法:采用国际龋病检测和评估系统(ICDAS)、牙周状况指数(PCI)和牙科有创治疗需求指数(INI)评估龋病经历指数:临床指数结果显示,FXS 患者的龋洞率和探诊出血率很高。将 VicRK 和 CovR 转录水平与参考株进行比较,发现脆性 X 患者的数值明显更高:本研究表明,FXS 患者的临床症状更为严重,生物膜积累和致病力都有所增强。结论:本研究表明,FXS 患者的临床状况更为不利,其生物膜积累和致病力都有所增强,如果再加上行为异常,这些患者就更容易患龋齿。
Assessment of dental and periodontal indices and Streptococcus mutans virulence in fragile X syndrome patients
Introduction
Fragile X syndrome (FXS) is the most common cause of hereditary genetic disorder in a single gene characterised by intellectual disability. Behavioural features such as autism, hyperactivity and anxiety disorder may be present. Biofilm development and pathogenicity of Streptococcus mutans may be altered because FXS renders the dental approach and oral hygiene more complex.
Objectives
The purpose of this study was to compare the levels of transcripts for VicRK and CovR of S. mutans isolated from FXS patients with the levels of transcripts for VicRK and CovR of standard strain ATCC, using a quantitative polymerase chain reaction (qPCR).
Methods
The caries experience index was assessed by the International Caries Detection and Assessment System (ICDAS), Periodontal Condition Index (PCI) and Invasive Dental Treatment Need Index (INI).
Results
The clinical index findings revealed a high rate of caries cavities and bleeding on probing of FXS patients. When VicRK and CovR transcript levels were compared with the reference strain, Fragile X patients were found to have significantly higher values.
Conclusion
The present study demonstrated that FXS patients have more adverse clinical conditions, with increased biofilm accumulation and virulence. When combined with behavioural abnormalities, these patients become even more vulnerable to dental caries.
期刊介绍:
The Journal of Intellectual Disability Research is devoted exclusively to the scientific study of intellectual disability and publishes papers reporting original observations in this field. The subject matter is broad and includes, but is not restricted to, findings from biological, educational, genetic, medical, psychiatric, psychological and sociological studies, and ethical, philosophical, and legal contributions that increase knowledge on the treatment and prevention of intellectual disability and of associated impairments and disabilities, and/or inform public policy and practice. Expert reviews on themes in which recent research has produced notable advances will be included. Such reviews will normally be by invitation.