Paweł Surowiak, Vladimir Tsepkolenko, Romuald Olszański
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引用次数: 0
摘要
富血小板血浆(PRP)作为一种自体生长因子来源,被广泛应用于不同的医学领域。目前,PRP 在美容医学中的应用日益频繁,其目的是活化皮肤。到目前为止,PRP 在健康人皮肤上的作用机制尚未被详细确认。本研究旨在探讨 PRP 对人体皮肤 I 型胶原蛋白合成的影响。本研究是一项前瞻性、单中心、单剂量、开放标签、非随机对照临床研究。研究对象是 10 名志愿者,他们的前臂皮肤注射了 PRP,而安慰剂对照组则注射了 0.9% 氯化钠。21 天后,使用免疫组化方法检测了 I 型胶原蛋白的表达情况。研究表明,使用 PRP 治疗的皮肤碎片的胶原蛋白表达明显高于安慰剂对照组。研究表明,PRP 能刺激健康人皮肤中胶原蛋白的表达。
Platelet-rich Plasma Stimulates Collagen Type I Synthesis in the Human Skin: A Placebo-controlledin vivo Study.
Platelet-rich plasma (PRP) is used in medicine as a source of autologous growth factors in different indications. At present, PRP is applied increasingly frequently in aesthetic medicine with the aim of skin revitalization. Until now, the mechanisms of PRP effects in healthy human skin treated with aesthetic goals have not been identified in detail. This study aimed to examine PRP effects on the synthesis of procollagen type I in human skin. This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. The study was conducted on a group of 10 volunteers in whom forearm skin was injected with PRP, while the placebo control group received injections of 0.9% NaCl. Expression of procollagen type I was examined after 21 days using immunohistochemistry. The study demonstrated that skin fragments subjected therapy using PRP demonstrated a significantly higher expression of procollagen than that which was observed in placebo controls. The study demonstrated that PRP stimulated collagen expression in healthy human skin.