一名冯-希佩尔-林道氏症患者的小脑肿瘤间转移。

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-05-01 Epub Date: 2024-05-07 DOI:10.1097/PAI.0000000000001197

Tengfei Wang, Lina Liu, Debby Rampisela, Xiuhua Dong, Kristin Alexndria Keith, Ethan A Benardete, Frank Y Shan

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引用次数: 0

摘要

中枢神经系统的肿瘤间转移在我们的日常工作中并不常见。大多数报告包括乳腺癌转移至脑膜瘤。在此，我们报告了一名患有冯-希佩尔-林道（VHL）病的患者，其透明细胞肾细胞癌（ccRCC）转移至小脑血管母细胞瘤。影像学检查无法区分转移性ccRCC和原发性小脑血管母细胞瘤。免疫分子研究被证明具有诊断意义。我们还回顾了之前记录的VHL病中ccRCC向小脑血管母细胞瘤的肿瘤间转移。最后，我们讨论了VHL患者的ccRCC向小脑血管母细胞瘤转移的潜在机制。

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A Cerebellar Tumor-to-Tumor Metastasis in a Patient With Von Hippel-Lindau Disease.

Tumor-to-tumor metastasis in the central nerve system is uncommon in our routine practice. Most reports include metastatic breast cancer into meningioma. Here we report a metastatic clear cell renal cell carcinoma (ccRCC) into a cerebellar hemangioblastoma in a patient with von Hippel-Lindau (VHL) disease. Imaging cannot distinguish metastatic ccRCC from primary cerebellar hemangioblastoma. Immuno-molecular studies are proven to be diagnostic. We also reviewed previously documented tumor-to-tumor metastasis of ccRCC to cerebellar hemangioblastoma in VHL disease. Lastly, we discussed potential mechanisms involved in the metastasis of ccRCC to hemangioblastoma in the cerebellum in patients with VHL.

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.